A
Ana Margarida Almeida
Researcher at University of Aveiro
Publications - 129
Citations - 1974
Ana Margarida Almeida is an academic researcher from University of Aveiro. The author has contributed to research in topics: Usability & Computer science. The author has an hindex of 12, co-authored 122 publications receiving 1604 citations. Previous affiliations of Ana Margarida Almeida include University of Porto & Institute of Molecular Pathology and Immunology of the University of Porto.
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Journal ArticleDOI
Frequency of TERT promoter mutations in human cancers.
João Vinagre,Ana Margarida Almeida,Ana Margarida Almeida,Helena Pópulo,Rui Batista,Joana Lyra,Joana Lyra,Vasco Pinto,Vasco Pinto,Ricardo Marques Coelho,Ricardo Marques Coelho,Ricardo Celestino,Hugo Prazeres,Luís Lima,Miguel Melo,Adriana Gaspar da Rocha,Adriana Gaspar da Rocha,Ana Preto,Ana Preto,Patrícia Castro,Lígia Castro,Fernando Pardal,José Manuel Lopes,José Manuel Lopes,Lúcio Lara Santos,Rui Manuel Reis,José Cameselle-Teijeiro,Manuel Sobrinho-Simões,Manuel Sobrinho-Simões,Jorge Lima,Jorge Lima,Valdemar Máximo,Valdemar Máximo,Paula Soares,Paula Soares +34 more
TL;DR: The results show that TERT promoter mutations are relatively frequent in specific types of human cancers, where they lead to enhanced expression of telomerase.
Journal ArticleDOI
TERT promoter mutations are a major indicator of poor outcome in differentiated thyroid carcinomas.
Miguel Melo,Miguel Melo,Adriana Gaspar da Rocha,Adriana Gaspar da Rocha,João Vinagre,João Vinagre,Rui Batista,Joana Peixoto,Catarina Tavares,Catarina Tavares,Ricardo Celestino,Ana Margarida Almeida,Ana Margarida Almeida,Alves Salgado Catarina Miguel,Catarina Eloy,Patrícia Castro,Hugo Prazeres,Jorge Lima,Teresina Amaro,Cláudia Lobo,Maria Joao Martins,Margarida Moura,Branca M. Cavaco,Valeriano Leite,José Cameselle-Teijeiro,Francisco Carrilho,Manuela Carvalheiro,Valdemar Máximo,Valdemar Máximo,Manuel Sobrinho-Simões,Manuel Sobrinho-Simões,Paula Soares,Paula Soares +32 more
TL;DR: TERT promoter mutations are an indicator of clinically aggressive tumors, being correlated with worse outcome and disease-specific mortality in DTC and, notably, in PTC, where they have an independent prognostic value.
Journal ArticleDOI
STAT3 negatively regulates thyroid tumorigenesis
Joana Couto,Joana Couto,Laura Daly,Ana Margarida Almeida,Ana Margarida Almeida,Jeffrey A. Knauf,James A. Fagin,Manuel Sobrinho-Simões,Manuel Sobrinho-Simões,Jorge Lima,Valdemar Máximo,Valdemar Máximo,Paula Soares,Paula Soares,David Lyden,Jacqueline Bromberg +15 more
TL;DR: These studies show that targeting STAT3 in these cancers could enhance tumor size and highlight the complexities of the role ofSTAT3 in tumorigenesis, and show that STAT3 is paradoxically a negative regulator of tumor growth.
Journal ArticleDOI
Cervical cancer and HPV infection: ongoing therapeutic research to counteract the action of E6 and E7 oncoproteins.
TL;DR: From well-established strategies, like DNA vaccines and gene therapy, to innovative gene silencing technologies; different methodologies are currently under scrutiny that target the E6 and E7 oncoproteins and/or their modes of action.
Journal ArticleDOI
Histamine monolith versatility to purify supercoiled plasmid deoxyribonucleic acid from Escherichia coli lysate.
TL;DR: In this article, the physicochemical properties of histamine ligand in a supercoiled plasmid DNA purification process from an Escherichia coli clarified lysate, where the emphasis is given to the elution strategy that allows higher selectivity and efficient removal of other impurities besides the open circular isoform.