Ana Rey-Rico

TL;DR: In this paper, a review of CD-based supramolecular nanosystems with a special focus on the advances materialized in the last five years, including clinical trials is presented.

TL;DR: Applying the candidate TGF‐β vector to human bone marrow aspirates was capable of reducing the hypertrophic and osteogenic differentiation processes in the aspirates, showing the potential benefits of using this particular vector to directly modify marrow concentrates to generate single‐step, effective approaches that aim at improving articular cartilage repair in vivo.

TL;DR: The findings show the benefits of targeting patients’ bone marrow via PCL film-guided therapeutic rAAV (sox9) delivery as an off-the-shelf system for future strategies to enhance cartilage repair in translational applications.

TL;DR: The aim of this work was to design for the first time hydrogel contact lenses that can act as platforms for the controlled delivery of viral vectors to the eye in an effective way with improved patient compliance.

TL;DR: An overview of the variety of biomaterials employed as nonviral or viral gene carriers for osteochondral repair approaches both in vitro and in vivo, including hydrogels, solid scaffolds, and hybrid materials shows that a site-specific delivery of therapeutic gene vectors in the context of acellular or cellular strategies allows for a spatial and temporal control of osteochondrals neotissue composition in vitro.