Ana Rey-Rico

TL;DR: The strong benefits of providing rAAV to human mesenchymal stem cells, a potent source of cells for regenerative medicine, encapsulated in polymeric micelles based on poly(ethylene oxide) (PEO) and poly(propylene oxide), triblock copolymers as novel, effective and safe delivery systems for human gene therapy are described.

TL;DR: The state of art of the application of PEO-PPO-PEO copolymers in both nonviral and viral gene transfer approaches and their potential as gene delivery systems in different regenerative medicine approaches are summarized.

TL;DR: In this paper, the authors summarize recent progress in the development of polysaccharide-based hydrogels of diverse nature, alone or in combination with other polymers or drug delivery systems, which have been implemented in the delivery of biotherapeutics in the pharmaceutical and biomedical fields.

TL;DR: The anti-P-gp activity is maxima for block copolymers possessing a low-to-medium hydrophilic-lipophilic balance and an 'effective number' of PO units ranging from 30 to 50.

TL;DR: The present study demonstrates that RAD16-I is an advantageous material with tunable properties to control the release of rAAV vectors as a promising tool to develop new, improved therapeutic approaches for tissue engineering in vivo.