Ana Rey-Rico

TL;DR: In light of promising preclinical data that may rapidly expand in a close future, biomaterial-guided viral gene therapy has a strong potential for translation in the field of human orthopaedic regenerative medicine.

TL;DR: The results demonstrate that successful, significant rAAV-mediated IGF-I gene transfer and expression were achieved in transduced aspirates, leading to increased levels of proliferation, matrix synthesis, and chondrogenic differentiation over time compared with the control condition.

TL;DR: A mechanism by which TGF‐β1 modulates early chon‐ drogenesis by primarily increasing the number of progenitor cells arising from the subchondral bone marrow compartment via the SDF‐1/chemokine (CXC motif) receptor 4 pathway, their proliferation, differentiation, and extracellular matrix deposition in specific topographic patterns is identified.

TL;DR: In this paper, a three-dimensional fibrin-polyurethane scaffold provided a favorable environment for the effective chondrogenic differentiation of human mesenchymal stem cells (MSCs) overexpressing the cartilage-specific SOX9 transcription factor via recombinant adeno-associated virus (rAAV)-mediated gene transfer.

TL;DR: The results indicate that the selected SO/EO ratio and copolymer block lengths were optimal for simultaneously achieving low critical micelle concentrations (cmc) values and large drug encapsulation ability.