A
André Kahan
Researcher at Paris Descartes University
Publications - 88
Citations - 3829
André Kahan is an academic researcher from Paris Descartes University. The author has contributed to research in topics: Population & Calcinosis. The author has an hindex of 35, co-authored 88 publications receiving 3447 citations.
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Journal ArticleDOI
Trends in mortality in patients with systemic sclerosis over 40 years: a systematic review and meta-analysis of cohort studies
TL;DR: The results confirm that SSc is a devastating condition as reflected by a pooled SMR of 3.5 and that SMR has not significantly changed over the past 40 years.
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High N-terminal pro-brain natriuretic peptide levels and low diffusing capacity for carbon monoxide as independent predictors of the occurrence of precapillary pulmonary arterial hypertension in patients with systemic sclerosis.
Yannick Allanore,Didier Borderie,Jérôme Avouac,D. Zerkak,Christophe Meune,Eric Hachulla,Luc Mouthon,Loïc Guillevin,O. Meyer,O. G. Ekindjian,Simon Weber,André Kahan +11 more
TL;DR: An increased NT-proBNP level together with a decreased DLCO/VA ratio of <70% was highly predictive of the occurrence of PAH during followup, and use of these markers should result in improved PAH risk stratification and allow earlier initiation of therapy.
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Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.
Yannick Allanore,Yannick Allanore,Mohamad Saad,Philippe Dieudé,Jérôme Avouac,Jérôme Avouac,Jörg H W Distler,Philippe Amouyel,Marco Matucci-Cerinic,G. Riemekasten,Paolo Airò,Inga Melchers,Eric Hachulla,Daniele Cusi,H.-Erich Wichmann,Julien Wipff,Julien Wipff,Jean-Charles Lambert,Nicolas Hunzelmann,Kiet Tiev,Paola Caramaschi,Elisabeth Diot,Otylia Kowal-Bielecka,Gabriele Valentini,Luc Mouthon,László Czirják,Nemanja Damjanov,Erika Salvi,Costanza Conti,Martina Müller,Ulf Müller-Ladner,Valeria Riccieri,Barbara Ruiz,Jean-Luc Cracowski,Luc Letenneur,Luc Letenneur,Anne Marie Dupuy,Oliver Meyer,André Kahan,Arnold Munnich,Catherine Boileau,Catherine Boileau,Maria Martinez +42 more
TL;DR: The genetic signal of association with TNIP1 variants, together with tissular and cellular investigations, suggests that this pathway has a critical role in regulating autoimmunity and SSc pathogenesis.
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Cardiac Involvement in Systemic Sclerosis Assessed by Tissue-Doppler Echocardiography During Routine Care A Controlled Study of 100 Consecutive Patients
Christophe Meune,Jérôme Avouac,Karim Wahbi,Laure Cabanes,Julien Wipff,Luc Mouthon,Loïc Guillevin,André Kahan,Yannick Allanore +8 more
TL;DR: Depression of LV and RV systolic and LV diastolic function is common in patients with SSc and is due to primary myocardial involvement, Considering the major contributions of TDI, the addition of this simple technique to standard measurements may improve the detection of heart involvement in patientswith SSc.
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Association between the IRF5 rs2004640 functional polymorphism and systemic sclerosis: A new perspective for pulmonary fibrosis
Philippe Dieudé,Mickaël Guedj,Julien Wipff,Jérôme Avouac,I. Fajardy,E. Diot,B. Granel,Jean Sibilia,J. Cabane,Luc Mouthon,Jean-Luc Cracowski,Patrick H. Carpentier,Eric Hachulla,Olivier Meyer,André Kahan,Catherine Boileau,Yannick Allanore +16 more
TL;DR: The IRF5 rs2004640 GT substitution is associated with susceptibility to SSc, and new insight into the pathogenesis of SSc is provided, including clues to the mechanisms leading to fibrosing alveolitis.