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André Renner
Researcher at Ruhr University Bochum
Publications - 47
Citations - 1580
André Renner is an academic researcher from Ruhr University Bochum. The author has contributed to research in topics: Transplantation & Internal medicine. The author has an hindex of 18, co-authored 43 publications receiving 1212 citations. Previous affiliations of André Renner include Heart and Diabetes Center North Rhine-Westphalia.
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Journal ArticleDOI
Inhibition of Elevated Ca2+/Calmodulin-Dependent Protein Kinase II Improves Contractility in Human Failing Myocardium
Samuel Sossalla,Nina Fluschnik,Hanna Schotola,Katharina Ort,Stefan Neef,Timo Schulte,Katrin Wittköpper,André Renner,Jan D. Schmitto,Jan Gummert,Ali El-Armouche,Gerd Hasenfuss,Lars S. Maier +12 more
TL;DR: CaMKII inhibition acutely improves contractility in human HF where CaMKII&dgr; expression is increased, and appears to be a possible therapeutic option for patients with HF and merits further investigation.
Journal ArticleDOI
Changes in m6A RNA methylation contribute to heart failure progression by modulating translation.
Tea Berulava,E Buchholz,Vakhtang Elerdashvili,Tonatiuh Pena,Rezaul Islam,Dawid Lbik,Belal A. Mohamed,André Renner,Dirk von Lewinski,Michael Sacherer,Katherine E. Bohnsack,Markus T. Bohnsack,Gaurav Jain,Vincenzo Capece,Nicole Cleve,Susanne Burkhardt,Gerd Hasenfuss,Andre Fischer,Andre Fischer,Karl Toischer +19 more
TL;DR: The potential relevance of m6A RNA methylation in heart failure development is studied and it is found that it may be important for the regulation of epigenetic processes and aberrant gene expression.
Journal ArticleDOI
Iron-regulatory proteins secure iron availability in cardiomyocytes to prevent heart failure.
Saba Haddad,Yong Wang,Bruno Galy,Mortimer Korf-Klingebiel,Valentin G. Hirsch,Abdul Mannan Baru,Fatemeh Rostami,Marc R. Reboll,Jörg Heineke,Ulrich Flögel,Stephanie Groos,André Renner,Karl Toischer,Fabian Zimmermann,Stefan Engeli,Jens Jordan,Johann Bauersachs,Matthias W. Hentze,Kai C. Wollert,Tibor Kempf +19 more
TL;DR: ID in cardiomyocytes impairs mitochondrial respiration and adaptation to acute and chronic increases in workload, and iron supplementation restores cardiac energy reserve and function in iron-deficient hearts.
Journal ArticleDOI
Empagliflozin directly improves diastolic function in human heart failure
Steffen Pabel,Steffen Pabel,Stefan Wagner,Hannah Bollenberg,Philipp Bengel,Árpád Kovács,Christian Schach,P Tirilomis,Julian Mustroph,André Renner,Jan Gummert,Thomas H. Fischer,Sophie Van Linthout,Carsten Tschöpe,Katrin Streckfuss-Bömeke,Gerd Hasenfuss,Lars S. Maier,Nazha Hamdani,Samuel Sossalla,Samuel Sossalla +19 more
TL;DR: This study aims to investigate whether empagliflozin may cause direct pleiotropic effects on the myocardium, and if so, what mechanisms cause these effects and how they are distributed.
Journal ArticleDOI
Ca2+/Calmodulin-Dependent Protein Kinase II and Protein Kinase A Differentially Regulate Sarcoplasmic Reticulum Ca2+ Leak in Human Cardiac Pathology
Thomas H. Fischer,Jonas Herting,Theodor Tirilomis,André Renner,Stefan Neef,Karl Toischer,David Ellenberger,Anna Förster,Jan D. Schmitto,Jan Gummert,Friedrich A. Schöndube,Gerd Hasenfuss,Lars S. Maier,Samuel Sossalla +13 more
TL;DR: In human hypertrophy, both CaMKII and PKA functionally regulate RyR2 and may induce SR Ca2+ leak andCaMKII inhibition may reflect a promising therapeutic target for the treatment of arrhythmias and contractile dysfunction.