André Schiefner

TL;DR: A crystallographic structure of trimeric AcrB determined at 2.9 and 3.0 angstrom resolution in space groups reveals three different monomer conformations representing consecutive states in a transport cycle, implying an alternating access mechanism and a novel peristaltic mode of drug transport by this type of transporter.

TL;DR: The arrangement of VC1 molecules in the crystal and complementary biochemical studies suggest a role for self-association in RAGE function and enhance understanding of the functional outcomes of S100 protein binding to RAGE.

TL;DR: The high resolution structure of ProX in complex with its ligands glycine betaine and proline betaine was determined and revealed that cation-π interactions between the positive charge of the quaternary amine of the ligands and three tryptophan residues forming a rectangular aromatic box are the key determinants of the high affinity binding of compatible solutes by ProX.

TL;DR: The novel transport model merges Jardetzky's alternate access pump mechanism with the rotating site catalysis of F(1)F(0) ATPase and suggests a working hypothesis for the transport mechanism of RND transporters in general.

TL;DR: Glucose monomycolate–loaded CD1b tetramers identify a subset of CD4+ T cells in patients with Mycobacterium tuberculosis infection.