K
Kay Diederichs
Researcher at University of Konstanz
Publications - 195
Citations - 15305
Kay Diederichs is an academic researcher from University of Konstanz. The author has contributed to research in topics: DNA polymerase & Bacterial outer membrane. The author has an hindex of 62, co-authored 184 publications receiving 14142 citations. Previous affiliations of Kay Diederichs include ETH Zurich & McGill University.
Papers
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Journal ArticleDOI
Linking crystallographic model and data quality.
P. Andrew Karplus,Kay Diederichs +1 more
TL;DR: Here, it is shown that despite their widespread use, Rmerge values are poorly suited for determining the high-resolution limit and that current standard protocols discard much useful data, and a statistic is introduced that estimates the correlation of an observed data set with the underlying (not measurable) true signal.
Journal ArticleDOI
Improved R-factors for diffraction data analysis in macromolecular crystallography
Kay Diederichs,P. Andrew Karplus +1 more
TL;DR: It is proved that Rsym is seriously flawed, because it has an implicit dependence on the redundancy of the data, and a corrected R-factor, Rmeas, is introduced as the equivalent robust indicator of data consistency.
Journal ArticleDOI
Siderophore-mediated iron transport: crystal structure of FhuA with bound lipopolysaccharide.
TL;DR: Sequence homologies and mutagenesis data are used to propose a structural mechanism for TonB-dependent siderophore-mediated transport across the outer membrane.
Journal ArticleDOI
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
Yanyong Kang,X. Edward Zhou,Xiang Gao,Yuanzheng He,Wei Liu,Andrii Ishchenko,Anton Barty,Thomas A. White,Oleksandr Yefanov,Gye Won Han,Qingping Xu,Parker W. de Waal,Jiyuan Ke,M. H. Eileen Tan,Chenghai Zhang,Arne Moeller,Graham M. West,Bruce D. Pascal,Ned Van Eps,Lydia N. Caro,Sergey A. Vishnivetskiy,Regina J. Lee,Kelly Suino-Powell,Xin Gu,Kuntal Pal,Jinming Ma,Xiaoyong Zhi,Sébastien Boutet,Garth J. Williams,Marc Messerschmidt,Cornelius Gati,Nadia A. Zatsepin,Dingjie Wang,Daniel James,Shibom Basu,Shatabdi Roy-Chowdhury,Chelsie E. Conrad,Jesse Coe,Haiguang Liu,Stella Lisova,Christopher Kupitz,Ingo Grotjohann,Raimund Fromme,Yi Jiang,Minjia Tan,Huaiyu Yang,Jun Li,Meitian Wang,Zhong Zheng,Dianfan Li,Nicole Howe,Yingming Zhao,Jörg Standfuss,Kay Diederichs,Yuhui Dong,Clinton S. Potter,Bridget Carragher,Martin Caffrey,Hualiang Jiang,Henry N. Chapman,John C. H. Spence,Petra Fromme,Uwe Weierstall,Oliver P. Ernst,Vsevolod Katritch,Vsevolod V. Gurevich,Patrick R. Griffin,Wayne L. Hubbell,Raymond C. Stevens,Vadim Cherezov,Karsten Melcher,H. Eric Xu +71 more
TL;DR: The crystal structure of a constitutively active form of human rhodopsin bound to a pre-activated form of the mouse visual arrestin is determined by serial femtosecond X-ray laser crystallography and provides a basis for understanding GPCR-mediated arrestin-biased signalling.
Journal ArticleDOI
Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism.
TL;DR: A crystallographic structure of trimeric AcrB determined at 2.9 and 3.0 angstrom resolution in space groups reveals three different monomer conformations representing consecutive states in a transport cycle, implying an alternating access mechanism and a novel peristaltic mode of drug transport by this type of transporter.