Jochen Graw

TL;DR: The findings demonstrate that germ-line mutations in p27Kip1 can predispose to the development of multiple endocrine tumors in both rats and humans.

TL;DR: In the striatum, a part of the basal ganglia affected in humans with a speech deficit due to a nonfunctional FOXP2 allele, it is found that medium spiny neurons have increased dendrite lengths and increased synaptic plasticity, suggesting that alterations in cortico-basal ganglia circuits might have been important for the evolution of speech and language in humans.

TL;DR: Comparison of C57BL/6J and C57bl/6N demonstrates a range of phenotypic differences that have the potential to impact upon penetrance and expressivity of mutational effects in these strains.

TL;DR: It is shown that, in the Pitx3-deficient aphakia (ak) mouse mutant, the mesDA system is malformed, suggesting that other neuronal systems compensate for the absence of the nigrostriatal pathway.

TL;DR: While rapamycin did extend lifespan, it ameliorated few studied aging phenotypes and had similar effects on many of these traits in young animals, indicating that these effects were not due to a modulation of aging, but rather related to aging-independent drug effects.