Simone Renner

TL;DR: This Review consolidates the key information on the currently available animal models of obesity and diabetes and highlights the advantages, limitations and important caveats of each of these models.

TL;DR: An overview of the current techniques for genetic modification of pigs and the transgenic pig models established for neurodegenerative diseases, cardiovascular diseases, cystic fibrosis, and diabetes mellitus is provided.

TL;DR: The first large animal model with impaired incretin function demonstrates an essential role of GIP for insulin secretion, proliferation ofβ-cells, and physiological expansion of β-cell mass.

TL;DR: A practical trio of animal models are suggested for future use: mice for genetic investigations, mechanistic evaluations or early studies to identify potential drug targets; rabbits for studies on ion channel function, repolarization or re-entrant arrhythmias; and pigs for preclinical translational studies to validate previous findings.

TL;DR: Diabetes mellitus destabilized microvascular vessels of the heart, affecting the amplitude of therapeutic neovascularization via rAAV in a translational large animal model of hibernating myocardium.