A
Andrea Kurzwernhart
Researcher at University of Vienna
Publications - 8
Citations - 453
Andrea Kurzwernhart is an academic researcher from University of Vienna. The author has contributed to research in topics: Reactivity (chemistry) & Cytotoxicity. The author has an hindex of 6, co-authored 8 publications receiving 431 citations.
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Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder
Andrea Kurzwernhart,Wolfgang Kandioller,Caroline Bartel,Simone Bächler,Robert Trondl,Gerhard Mühlgassner,Michael A. Jakupec,Vladimir B. Arion,Doris Marko,Bernhard K. Keppler,Christian G. Hartinger,Christian G. Hartinger +11 more
TL;DR: Ru(II)(arene)-flavonoids with high in vitro antitumour activity were synthesised and are capable of inhibiting human topoisomerase IIα and binding covalently to DNA.
Journal ArticleDOI
Structure–Activity Relationships of Targeted RuII(η6-p-Cymene) Anticancer Complexes with Flavonol-Derived Ligands
Andrea Kurzwernhart,Wolfgang Kandioller,Simone Bächler,Caroline Bartel,Sanela Martic,Magdalena Buczkowska,Gerhard Mühlgassner,Michael A. Jakupec,Heinz-Bernhard Kraatz,Patrick J. Bednarski,Vladimir B. Arion,Doris Marko,Bernhard K. Keppler,Christian G. Hartinger,Christian G. Hartinger +14 more
TL;DR: Compared to the flavonol ligands, the RuII(η6-p-cymene) complexes are more potent antiproliferative agents, which can be explained by potential multitargeted properties.
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Pyrone derivatives and metals: From natural products to metal-based drugs
Wolfgang Kandioller,Andrea Kurzwernhart,Muhammad Hanif,Samuel M. Meier,Helena Henke,Bernhard K. Keppler,Christian G. Hartinger +6 more
TL;DR: Recent literature on the use of (thio)pyr(id)ones in bioinorganic chemistry with a focus on their metal ion chelating properties is summarized.
Journal ArticleDOI
3-Hydroxyflavones vs. 3-hydroxyquinolinones: structure–activity relationships and stability studies on RuII(arene) anticancer complexes with biologically active ligands
Andrea Kurzwernhart,Wolfgang Kandioller,Éva A. Enyedy,Maria S. Novak,Michael A. Jakupec,Bernhard K. Keppler,Christian G. Hartinger,Christian G. Hartinger +7 more
TL;DR: To expand knowledge about the structure-activity relationships and to determine the impact of lipophilicity of the arene ligand and of the hydrolysis rate on anticancer activity, a series of novel 3-hydroxyflavone derived Ru(II)(η(6)-arene) complexes were synthesised.
Journal ArticleDOI
Flavonoid‐Based Organometallics with Different Metal Centers – Investigations of the Effects on Reactivity and Cytotoxicity
Andrea Kurzwernhart,Stephan Mokesch,Erik Klapproth,Mahsa S. Adib-Ravazi,Michael A. Jakupec,Christian G. Hartinger,Wolfgang Kandioller,Bernhard K. Keppler +7 more
TL;DR: The flavonol scaffold is confirmed as a promising O,O-chelating ligand system for the development of anticancer active organometallics and exhibits in vitro anticancer activities in the high nM to low μM range.