M
Maria S. Novak
Researcher at University of Vienna
Publications - 15
Citations - 610
Maria S. Novak is an academic researcher from University of Vienna. The author has contributed to research in topics: Aqueous solution & Ruthenium. The author has an hindex of 13, co-authored 15 publications receiving 540 citations.
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Journal ArticleDOI
Novel metal(II) arene 2-pyridinecarbothioamides: a rationale to orally active organometallic anticancer agents
Samuel M. Meier,Muhammad Hanif,Muhammad Hanif,Zenita Adhireksan,Verena Pichler,Maria S. Novak,Elisabeth Jirkovsky,Michael A. Jakupec,Vladimir B. Arion,Curt A. Davey,Bernhard K. Keppler,Christian G. Hartinger,Christian G. Hartinger +12 more
TL;DR: A novel series of organometallic antitumour agents based on RuII and OsII complexes containing N-substituted 2-pyridinecarbothioamides (PCAs) has been synthesized and characterized and revealed a similar drug-likeness compared to erlotinib, tamoxifen, imatinib and sorafenib.
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3-Hydroxyflavones vs. 3-hydroxyquinolinones: structure–activity relationships and stability studies on RuII(arene) anticancer complexes with biologically active ligands
Andrea Kurzwernhart,Wolfgang Kandioller,Éva A. Enyedy,Maria S. Novak,Michael A. Jakupec,Bernhard K. Keppler,Christian G. Hartinger,Christian G. Hartinger +7 more
TL;DR: To expand knowledge about the structure-activity relationships and to determine the impact of lipophilicity of the arene ligand and of the hydrolysis rate on anticancer activity, a series of novel 3-hydroxyflavone derived Ru(II)(η(6)-arene) complexes were synthesised.
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Antitumor pentamethylcyclopentadienyl rhodium complexes of maltol and allomaltol: synthesis, solution speciation and bioactivity.
Orsolya Dömötör,Sabine Aicher,Melanie Schmidlehner,Maria S. Novak,Alexander Roller,Michael A. Jakupec,Wolfgang Kandioller,Christian G. Hartinger,Bernhard K. Keppler,Éva A. Enyedy +9 more
TL;DR: The organometallic compounds showed similar cytotoxicity profiles and were proved to be moderately active against various human cancer cell lines and higher conditional stabilities were found in the case of the Rh(III) compounds at pH7.4.
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Conjugation of organoruthenium(II) 3-(1H-benzimidazol-2-yl)pyrazolo[3,4-b]pyridines and indolo[3,2-d]benzazepines to recombinant human serum albumin: a strategy to enhance cytotoxicity in cancer cells.
Iryna N. Stepanenko,Angela Casini,Fabio Edafe,Maria S. Novak,Vladimir B. Arion,Paul J. Dyson,Michael A. Jakupec,Bernhard K. Keppler +7 more
TL;DR: To improve their antiproliferative effects, as well as their drug targeting and delivery to cancer cells, 1c–5c were conjugated to recombinant human serum albumin, potentially exploiting the so-called “enhanced permeability and retention” effect that results in the accumulation of macromolecules in tumors.
Journal ArticleDOI
Identification of the structural determinants for anticancer activity of a ruthenium arene peptide conjugate.
Samuel M. Meier,Maria S. Novak,Wolfgang Kandioller,Michael A. Jakupec,Vladimir B. Arion,Nils Metzler-Nolte,Bernhard K. Keppler,Christian G. Hartinger,Christian G. Hartinger +8 more
TL;DR: A conjugate of a Ru(arene) complex with the neuropeptide [Leu(5)]-enkephalin shows antiproliferative activity in human ovarian carcinoma cells with an IC50 value as low as 13 μM, whereas the peptide or the Ru moiety alone are hardly cytotoxic.