Andrea Kurzwernhart

TL;DR: Ru(II)(arene)-flavonoids with high in vitro antitumour activity were synthesised and are capable of inhibiting human topoisomerase IIα and binding covalently to DNA.

TL;DR: Compared to the flavonol ligands, the RuII(η6-p-cymene) complexes are more potent antiproliferative agents, which can be explained by potential multitargeted properties.

TL;DR: Recent literature on the use of (thio)pyr(id)ones in bioinorganic chemistry with a focus on their metal ion chelating properties is summarized.

TL;DR: To expand knowledge about the structure-activity relationships and to determine the impact of lipophilicity of the arene ligand and of the hydrolysis rate on anticancer activity, a series of novel 3-hydroxyflavone derived Ru(II)(η(6)-arene) complexes were synthesised.

TL;DR: The flavonol scaffold is confirmed as a promising O,O-chelating ligand system for the development of anticancer active organometallics and exhibits in vitro anticancer activities in the high nM to low μM range.