Andrea Repele

TL;DR: It is demonstrated that tail vein transplantation of mouse amniotic fluid stem (AFS) cells enhances the muscle strength and improves the survival rate of the affected animals and secondary transplants of satellite cells derived from treated mice show that AFS cells integrate into the muscle stem cell compartment and have long‐term muscle regeneration capacity indistinguishable from that of wild‐type‐derived SC.

TL;DR: It is shown here that hAFSCs under selective culture conditions are able to give rise to functional SMCs, for the first time that efficient SMCs can be obtained from human amniotic fluid stem cells.

TL;DR: The hanging drop system is used to culture SCs in a three‐dimensional environment and thus, to monitor them in their original niche and to solve the mixture of their subpopulations that exist within muscle.

TL;DR: These experimental observations report novel physiological features in the cell biology of SCs and refer to an intrinsic heterogeneity within which their stemness may reside.

TL;DR: In this article , a cell-intrinsic selection system that leverages the dependency of primary T cells on IL-2 signaling was proposed to enrich and expand therapeutic cells at clinical scale.