Andreas Gille

TL;DR: It is concluded thatFFAR3-mRFP serves as a useful marker for the majority of enteroendocrine cells of the small and large intestine and that FFAR3 and FFAR2 both act as sensors for short-chain fatty acids in entero endocrine cells, whereas FFAR 3 apparently has this role alone in enteric neurons and FFar2 in enterIC leukocytes.

TL;DR: The data clearly indicate that GPR109A mediates nicotinic acid-induced flushing and that this effect involves release of PGE(2) and PGD(2), most likely from immune cells of the skin.

TL;DR: The data show that lactate can directly modulate metabolic processes in a hormone-like manner, and they reveal a new mechanism underlying the antilipolytic effects of insulin.

TL;DR: It is demonstrated that a substance released by exercising skeletal muscle induces supportive effects in brain through an identified receptor, HCAR1, in wild-type mice.

TL;DR: New drugs acting via the nicotinic acid receptor or related receptors, as well as new co-medications that suppress unwanted effects of nicotinIC acid, will most likely be introduced as new therapeutic options in the treatment of dyslipidemia and the prevention of cardiovascular diseases.