M
Mark K. Nøhr
Researcher at Aarhus University
Publications - 12
Citations - 1704
Mark K. Nøhr is an academic researcher from Aarhus University. The author has contributed to research in topics: Enteroendocrine cell & Inflammation. The author has an hindex of 12, co-authored 12 publications receiving 1365 citations. Previous affiliations of Mark K. Nøhr include University Health Network & University of Copenhagen.
Papers
More filters
Journal ArticleDOI
GPR41/FFAR3 and GPR43/FFAR2 as Cosensors for Short-Chain Fatty Acids in Enteroendocrine Cells vs FFAR3 in Enteric Neurons and FFAR2 in Enteric Leukocytes
Mark K. Nøhr,Maria Pedersen,Andreas Gille,Kristoffer L. Egerod,Maja S. Engelstoft,Anna Sofie Husted,Rasmus M. Sichlau,Kaare V. Grunddal,Steen Seier Poulsen,Sangdon Han,Sangdon Han,Robert M. Jones,Stefan Offermanns,Thue W. Schwartz +13 more
TL;DR: It is concluded thatFFAR3-mRFP serves as a useful marker for the majority of enteroendocrine cells of the small and large intestine and that FFAR3 and FFAR2 both act as sensors for short-chain fatty acids in entero endocrine cells, whereas FFAR 3 apparently has this role alone in enteric neurons and FFar2 in enterIC leukocytes.
Journal ArticleDOI
A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin
Kristoffer L. Egerod,Maja S. Engelstoft,Kaare V. Grunddal,Mark K. Nøhr,Anna Secher,Ichiro Sakata,Jens Pedersen,Johanne Agerlin Windeløv,Ernst-Martin Füchtbauer,Jørgen Olsen,Frank Sundler,Jan Pravsgaard Christensen,Nils Wierup,Jesper V. Olsen,Jens J. Holst,Jeffrey M. Zigman,Steen Seier Poulsen,Thue W. Schwartz +17 more
TL;DR: It is concluded that a lineage of mature enteroendocrine cells have the ability to coexpress members of a group of functionally related peptides: CCK, secretin, GIP, GLP-1, PYY, and neurotensin, suggesting a potential therapeutic target for the treatment and prevention of diabetes and obesity.
Journal ArticleDOI
Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells
Maja S. Engelstoft,Won-Mee Park,Ichiro Sakata,Line Vildbrad Kristensen,Anna Sofie Husted,Sherri Osborne-Lawrence,Paul K Piper,Angela K. Walker,Maria Pedersen,Mark K. Nøhr,Jie Pan,Christopher Joseph Sinz,Paul E. Carrington,Taro E. Akiyama,Robert M. Jones,Cong Tang,Kashan Ahmed,Stefan Offermanns,Kristoffer L. Egerod,Jeffrey M. Zigman,Thue W. Schwartz +20 more
TL;DR: Highly expressed and enriched 7TM receptors and associated Gα subunits constitute a major part of the molecular machinery directly mediating neuronal and endocrine stimulation versus metabolite and somatostatin inhibition of ghrelin secretion including a series of novel receptor targets not previously identified on the gh Relin cell.
Journal ArticleDOI
Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia.
Mark K. Nøhr,Kristoffer L. Egerod,Søren H. Christiansen,Andreas Gille,Stefan Offermanns,Thue W. Schwartz,Morten Møller +6 more
TL;DR: Data indicate that FFAR3 is expressed on postganglionic sympathetic and sensory neurons in both the autonomic and somatic peripheral nervous system and that SCFAs act not only through the enteroendocrine system but also directly by modifying physiological reflexes integrating the peripheral nervous System and the gastro-intestinal tract.
Journal ArticleDOI
Neurotensin Is Coexpressed, Coreleased, and Acts Together With GLP-1 and PYY in Enteroendocrine Control of Metabolism.
Kaare V. Grunddal,Cecilia F. Ratner,Berit Svendsen,Berit Svendsen,Felix Sommer,Maja S. Engelstoft,Andreas N. Madsen,Jens Pedersen,Jens Pedersen,Mark K. Nøhr,Kristoffer L. Egerod,Andrea R. Nawrocki,Timothy J. Kowalski,Andrew D. Howard,Steen Seier Poulsen,Stefan Offermanns,Fredrik Bäckhed,Fredrik Bäckhed,Jens J. Holst,Jens J. Holst,Birgitte Holst,Thue W. Schwartz +21 more
TL;DR: In this paper, the anatomical and functional consequences of coexpression of neurotensin with glucagon-like peptide-1 and peptide YY in the distal small intestine were investigated.