K
Kristoffer L. Egerod
Researcher at University of Copenhagen
Publications - 50
Citations - 3574
Kristoffer L. Egerod is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Enteroendocrine cell & Receptor. The author has an hindex of 27, co-authored 47 publications receiving 2925 citations. Previous affiliations of Kristoffer L. Egerod include Novo Nordisk Foundation.
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Journal ArticleDOI
GPR41/FFAR3 and GPR43/FFAR2 as Cosensors for Short-Chain Fatty Acids in Enteroendocrine Cells vs FFAR3 in Enteric Neurons and FFAR2 in Enteric Leukocytes
Mark K. Nøhr,Maria Pedersen,Andreas Gille,Kristoffer L. Egerod,Maja S. Engelstoft,Anna Sofie Husted,Rasmus M. Sichlau,Kaare V. Grunddal,Steen Seier Poulsen,Sangdon Han,Sangdon Han,Robert M. Jones,Stefan Offermanns,Thue W. Schwartz +13 more
TL;DR: It is concluded thatFFAR3-mRFP serves as a useful marker for the majority of enteroendocrine cells of the small and large intestine and that FFAR3 and FFAR2 both act as sensors for short-chain fatty acids in entero endocrine cells, whereas FFAR 3 apparently has this role alone in enteric neurons and FFar2 in enterIC leukocytes.
Journal ArticleDOI
GPR39 Signaling Is Stimulated by Zinc Ions But Not by Obestatin
Birgitte Holst,Kristoffer L. Egerod,Enrico Schild,Steve Vickers,Sharon C. Cheetham,Lars-Ole Gerlach,Laura Storjohann,Carsten Enggaard Stidsen,Robert G. Jones,Annette G. Beck-Sickinger,Thue W. Schwartz +10 more
TL;DR: It is concluded that GPR39 is probably not the obestatin receptor and the potency and efficacy of Zn(2+) in respect of activating signaling indicates that this metal ion could be a physiologically relevant agonist or modulator of G PR39.
Journal ArticleDOI
A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin
Kristoffer L. Egerod,Maja S. Engelstoft,Kaare V. Grunddal,Mark K. Nøhr,Anna Secher,Ichiro Sakata,Jens Pedersen,Johanne Agerlin Windeløv,Ernst-Martin Füchtbauer,Jørgen Olsen,Frank Sundler,Jan Pravsgaard Christensen,Nils Wierup,Jesper V. Olsen,Jens J. Holst,Jeffrey M. Zigman,Steen Seier Poulsen,Thue W. Schwartz +17 more
TL;DR: It is concluded that a lineage of mature enteroendocrine cells have the ability to coexpress members of a group of functionally related peptides: CCK, secretin, GIP, GLP-1, PYY, and neurotensin, suggesting a potential therapeutic target for the treatment and prevention of diabetes and obesity.
Journal ArticleDOI
Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells
Maja S. Engelstoft,Won-Mee Park,Ichiro Sakata,Line Vildbrad Kristensen,Anna Sofie Husted,Sherri Osborne-Lawrence,Paul K Piper,Angela K. Walker,Maria Pedersen,Mark K. Nøhr,Jie Pan,Christopher Joseph Sinz,Paul E. Carrington,Taro E. Akiyama,Robert M. Jones,Cong Tang,Kashan Ahmed,Stefan Offermanns,Kristoffer L. Egerod,Jeffrey M. Zigman,Thue W. Schwartz +20 more
TL;DR: Highly expressed and enriched 7TM receptors and associated Gα subunits constitute a major part of the molecular machinery directly mediating neuronal and endocrine stimulation versus metabolite and somatostatin inhibition of ghrelin secretion including a series of novel receptor targets not previously identified on the gh Relin cell.
Journal ArticleDOI
Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia.
Mark K. Nøhr,Kristoffer L. Egerod,Søren H. Christiansen,Andreas Gille,Stefan Offermanns,Thue W. Schwartz,Morten Møller +6 more
TL;DR: Data indicate that FFAR3 is expressed on postganglionic sympathetic and sensory neurons in both the autonomic and somatic peripheral nervous system and that SCFAs act not only through the enteroendocrine system but also directly by modifying physiological reflexes integrating the peripheral nervous System and the gastro-intestinal tract.