A
Andreas Ludwig
Researcher at University of Leoben
Publications - 357
Citations - 7732
Andreas Ludwig is an academic researcher from University of Leoben. The author has contributed to research in topics: Equiaxed crystals & Continuous casting. The author has an hindex of 40, co-authored 335 publications receiving 6580 citations. Previous affiliations of Andreas Ludwig include RWTH Aachen University & École Polytechnique Fédérale de Lausanne.
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Journal ArticleDOI
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.
Christian Hundhausen,Dominika Misztela,Theo A. Berkhout,Neil Broadway,Paul Saftig,Karina Reiss,Dieter H. Hartmann,Falk Fahrenholz,Rolf Postina,Vance B. Matthews,Karl-Josef Kallen,Stefan Rose-John,Andreas Ludwig +12 more
TL;DR: It is demonstrated that ADAM10 is involved in the constitutive cleavage of CX3CL1 and thereby may regulate the recruitment of monocytic cells to CX2CL1-expressing cell layers and prevent de-adhesion of bound THP-1 cells.
Journal ArticleDOI
The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart
Juliane Stieber,Stefan Herrmann,Susanne Feil,Jana Löster,Robert Feil,Martin Biel,Franz Hofmann,Andreas Ludwig +7 more
TL;DR: It is shown that HCN4 is essential for the proper function of the developing cardiac conduction system and the proper generation of pacemaker potentials in the emerging sinoatrial node.
Journal ArticleDOI
Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3
Martin Biel,Mathias W. Seeliger,Alexander Pfeifer,Konrad Kohler,Andrea Gerstner,Andreas Ludwig,Gesine B. Jaissle,Sascha Fauser,Eberhart Zrenner,Franz Hofmann +9 more
TL;DR: CNG3-deficient mice provide an animal model to dissect unequivocally the contribution of rod and cone pathways for normal retinal function and the functional loss of cone function correlates with a progressive degeneration of cone photoreceptors but not of other retinal cell types.
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Chemokine Receptor CXCR6-Dependent Hepatic NK T Cell Accumulation Promotes Inflammation and Liver Fibrosis
Alexander Wehr,Christer Baeck,Felix Heymann,Patricia Maria Niemietz,Linda Hammerich,Christian Martin,Henning W. Zimmermann,Oliver Pack,Nikolaus Gassler,Kanishka Hittatiya,Andreas Ludwig,Tom Luedde,Christian Trautwein,Frank Tacke +13 more
TL;DR: It is demonstrated that hepatic NKT cells accumulate CXCR6-dependent early upon injury, thereby accentuating the inflammatory response in the liver and promoting hepatic fibrogenesis.
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Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state
Masayuki Shimoda,Simona Principe,Hartland W. Jackson,Valbona Luga,Hui Fang,Sam D. Molyneux,Yang W. Shao,Alison Aiken,Paul Waterhouse,Christina Karamboulas,Franz M. Hess,Takashi Ohtsuka,Yasunori Okada,Laurie Ailles,Andreas Ludwig,Jeffrey L. Wrana,Thomas Kislinger,Rama Khokha +17 more
TL;DR: Generating quadruple TIMP knockout (TIMPless) fibroblasts is generated to unleash metalloproteinase activity within the tumour-stromal compartment and it is shown that complete Timp loss is sufficient for the acquisition of hallmark CAF functions.