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Andreas Pikis
Researcher at Center for Drug Evaluation and Research
Publications - 9
Citations - 812
Andreas Pikis is an academic researcher from Center for Drug Evaluation and Research. The author has contributed to research in topics: Human cytomegalovirus & Surrogate endpoint. The author has an hindex of 6, co-authored 9 publications receiving 579 citations.
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Journal ArticleDOI
Definitions of Cytomegalovirus Infection and Disease in Transplant Patients for Use in Clinical Trials.
Per Ljungman,Per Ljungman,Michael Boeckh,Michael Boeckh,Hans H. Hirsch,Filip Josephson,Jens D Lundgren,Garrett Nichols,Andreas Pikis,Raymund R. Razonable,Veronica Miller,Paul D. Griffiths +11 more
TL;DR: The main changes compared to previous definitions are the introduction of a "probable disease" category and to incorporate quantitative nucleic acid testing in some end-organ disease categories.
Journal ArticleDOI
Use of Viral Load as a Surrogate Marker in Clinical Studies of Cytomegalovirus in Solid Organ Transplantation: A Systematic Review and Meta-analysis.
Yoichiro Natori,Ali Alghamdi,Mahmood Tazari,Veronica Miller,Shahid Husain,Takashi E. Komatsu,Paul D. Griffiths,Per Ljungman,Ani Orchanian-Cheff,Deepali Kumar,Atul Humar,Rekha Abichandani,Barbara D. Alexander,Robin K. Avery,Fausto Baldanti,Susan Barnett,Paul Baum,M Michelle Berrey,Debra Birnkrant,Emily A. Blumberg,Michael Boeckh,David Boutolleau,Terry Bowlin,Jennifer Brooks,Roy F. Chemaly,Sunwen Chou,Gavin Cloherty,William Cruikshank,Lesia K. Dropulic,Hermann Einsele,Jay Erdman,Gary Fahle,Lynn Fallon,Heather Gillis,Dimitri Gonzalez,Kurt Gunter,Hans H. Hirsch,Aimee Hodowanec,Peter W. Hunt,Filip Josephson,Camille N. Kotton,Philip R. Krause,Frank Kuhr,Christopher Lademacher,Randall Lanier,Tadd Lazarus,John A. D. Leake,Randi Y. Leavitt,Sandra Nusinoff Lehrman,Li Li,Paula Isabelle Lodding,Jens D Lundgren,Francisco Martinez-Murillo,Howard Mayer,Megan McCutcheon,John E. McKinnon,Thomas Mertens,Kevin Modarress,Johann Mols,Sally Mossman,Yoshihiko Murata,David Murawski,Jeffrey C. Murray,Garrett Nichols,Jules O'Rear,Karl S. Peggs,Andreas Pikis,Mark N. Prichard,Raymund R. Razonable,Marcie L. Riches,Jeff Roberts,Wael Saber,Chalom Sayada,Mary Singer,Thomas Stamminger,Anna Wijatyk,Dong Yu,Bernhardt Zeiher +77 more
TL;DR: It is concluded that CMV load is an appropriate surrogate endpoint for CMV trials in organ transplant recipients due to low frequency of disease and several lines of evidence support the validity of viral load.
Journal ArticleDOI
Resistance of Human Cytomegalovirus to Ganciclovir/Valganciclovir: A Comprehensive Review of Putative Resistance Pathways
TL;DR: It is proposed that there are more potential HCMV ganciclovir/valganciclovirs resistance pathways than generally appreciated and also provided insight regarding the potential for cross-resistance to other H CMV therapies.
Journal ArticleDOI
Enterococcus faecalis utilizes maltose by connecting two incompatible metabolic routes via a novel maltose 6'-phosphate phosphatase (MapP).
Abdelhamid Mokhtari,Victor Sebastian Blancato,Guillermo Daniel Repizo,Céline Henry,Céline Henry,Andreas Pikis,Alexa Bourand,Alexa Bourand,Alexa Bourand,María de Fátima Álvarez,Stefan Immel,Aicha Mechakra-Maza,Axel Hartke,John F. Thompson,Christian Magni,Josef Deutscher,Josef Deutscher,Josef Deutscher +17 more
TL;DR: Dephosphorylation assays with a wide variety of phospho‐substrates revealed that MapP preferably dephosphorylates disaccharides containing an O‐α‐glycosyl linkage, which connects PTS‐mediated maltose uptake to maltose phosphorylase‐catalysed metabolism.
Journal ArticleDOI
Enterococcus faecalis Uses a Phosphotransferase System Permease and a Host Colonization-Related ABC Transporter for Maltodextrin Uptake.
Nicolas Sauvageot,Abdelhamid Mokhtari,Philippe Joyet,Aurélie Budin-Verneuil,Victor Sebastian Blancato,Guillermo Daniel Repizo,Céline Henry,Andreas Pikis,John F. Thompson,Christian Magni,Axel Hartke,Josef Deutscher +11 more
TL;DR: In this article, a detailed study of maltodextrin transport in E. faecalis was carried out, and it was shown that the use of Maltodextrins as a source of carbon and energy was linked to its virulence.