Garrett Nichols

TL;DR: The main changes compared to previous definitions are the introduction of a "probable disease" category and to incorporate quantitative nucleic acid testing in some end-organ disease categories.

TL;DR: In this article, the authors used quantitative PCR to test for cytomegalovirus, BK polyomavirus, human herpesvirus 6B, HHV-6A, adenovirus and Epstein-Barr virus between days 0 and 100 post-HCT.

TL;DR: It is concluded that CMV load is an appropriate surrogate endpoint for CMV trials in organ transplant recipients due to low frequency of disease and several lines of evidence support the validity of viral load.

TL;DR: Persistent high viral load dsDNA viremia episodes after allogeneic HCT predict mortality, and virus-specific kinetics can guide timing and thresholds for early intervention in studies of novel agents.

TL;DR: The incidence of AdV infection decreased stepwise with increasing age; younger adults (age 18 to 34 years) had a similar incidence as older pediatric patients (<18 years), and this study provides a contemporary multicenter understanding of the incidence and risk factors for Adv infection following allo-HCT.