Andreas T. Björklund

TL;DR: It is shown that CD56(dim) NK cells continue to differentiate, and the associated functional imprint, occurs independently of NK-cell education by interactions with self-human leukocyte antigen class I ligands and is an essential part of the formation of human NK- cell repertoires.

TL;DR: Advances in human NK cell research are discussed, many of which support the ability of NK cells to prevent cancer development and avoid relapse following adoptive immunotherapy, and the molecular basis for NK cell recognition of human tumor cells is described and evidence forNK cell-mediated killing of human primary tumor cells ex vivo is provided.

TL;DR: Investigation of the effects of induction chemotherapy, conditioning radiochemotherapy, and allogeneic HSCT on composition, phenotype, and recovery of circulating innate lymphoid cells in 51 acute leukemia patients suggests that ILC recovery and treatment-related tissue damage are interrelated and affect the development of GVHD.

TL;DR: The literature is reviewed and how the TME manipulates the NK cell phenotypes, genotypes, and tropism to evade tumor recognition and elimination is highlighted.

TL;DR: This study suggests that high-risk MDS is responsive toNK-cell therapy and supports the use of haploidentical NK-cell infusions as a bridge to HSCT in refractory patients.