Journal ArticleDOI
Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education
Niklas K. Björkström,Peggy Riese,Frank Heuts,Sandra Andersson,Cyril Fauriat,Cyril Fauriat,Martin A. Ivarsson,Andreas T. Björklund,Malin Flodström-Tullberg,Jakob Michaëlsson,Martin E. Rottenberg,Carlos A. Guzmán,Hans-Gustaf Ljunggren,Karl-Johan Malmberg +13 more
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TLDR
It is shown that CD56(dim) NK cells continue to differentiate, and the associated functional imprint, occurs independently of NK-cell education by interactions with self-human leukocyte antigen class I ligands and is an essential part of the formation of human NK- cell repertoires.About:
This article is published in Blood.The article was published on 2010-11-11. It has received 622 citations till now. The article focuses on the topics: Natural killer cell & Lymphokine-activated killer cell.read more
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Journal ArticleDOI
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
Andrea Cossarizza,Hyun-Dong Chang,Andreas Radbruch,Andreas Acs,Dieter Adam,Sabine Adam-Klages,William W. Agace,William W. Agace,Nima Aghaeepour,Mübeccel Akdis,Matthieu Allez,Larissa Nogueira Almeida,Giorgia Alvisi,Graham Anderson,Immanuel Andrä,Francesco Annunziato,Achille Anselmo,Petra Bacher,Cosima T. Baldari,Sudipto Bari,Vincenzo Barnaba,Vincenzo Barnaba,Joana Barros-Martins,Luca Battistini,Wolfgang Bauer,Sabine Baumgart,Nicole Baumgarth,Dirk Baumjohann,Bianka Baying,Mary Bebawy,Burkhard Becher,Wolfgang Beisker,Vladimir Benes,Rudi Beyaert,Alfonso Blanco,Dominic A. Boardman,Christian Bogdan,Jessica G. Borger,Giovanna Borsellino,Philip E. Boulais,Jolene Bradford,Dirk Brenner,Dirk Brenner,Ryan R. Brinkman,Anna E. S. Brooks,Dirk H. Busch,Martin Büscher,Timothy P. Bushnell,Federica Calzetti,Garth Cameron,Ilenia Cammarata,Xuetao Cao,Susanna Cardell,Stefano Casola,Marco A. Cassatella,Andrea Cavani,Antonio Celada,Lucienne Chatenoud,Pratip K. Chattopadhyay,Sue Chow,Eleni Christakou,Eleni Christakou,Luka Cicin-Sain,Mario Clerici,Federico Colombo,Laura Cook,Anne Cooke,Andrea M. Cooper,Alexandra J. Corbett,Antonio Cosma,Lorenzo Cosmi,Pierre Coulie,Ana Cumano,Ljiljana Cvetkovic,Van Duc Dang,Chantip Dang-Heine,Martin S. Davey,Derek Davies,Sara De Biasi,Genny Del Zotto,Gelo Victoriano Dela Cruz,Michael Delacher,Silvia Della Bella,Paolo Dellabona,Günnur Deniz,Mark C. Dessing,James P. Di Santo,Andreas Diefenbach,Francesco Dieli,Andreas Dolf,Thomas Dörner,Regine J. Dress,Diana Dudziak,Michael L. Dustin,Charles-Antoine Dutertre,Charles-Antoine Dutertre,Friederike Ebner,Sidonia B G Eckle,Matthias Edinger,Pascale Eede,Götz R. A. Ehrhardt,Marcus Eich,Pablo Engel,Britta Engelhardt,Anna Erdei,Charlotte Esser,Bart Everts,Maximilien Evrard,Christine S. Falk,Todd A. Fehniger,Mar Felipo-Benavent,Helen Ferry,Markus Feuerer,Andrew Filby,Kata Filkor,Simon Fillatreau,Marie Follo,Irmgard Förster,John Bellamy Foster,Gemma A. Foulds,Britta Frehse,Paul S. Frenette,Stefan Frischbutter,Wolfgang Fritzsche,David W. Galbraith,David W. Galbraith,Anastasia Gangaev,Natalio Garbi,Brice Gaudilliere,Ricardo T. Gazzinelli,Ricardo T. Gazzinelli,Jens Geginat,Wilhelm Gerner,Nicholas A Gherardin,Kamran Ghoreschi,Lara Gibellini,Florent Ginhoux,Florent Ginhoux,Florent Ginhoux,Keisuke Goda,Keisuke Goda,Keisuke Goda,Dale I. Godfrey,Christoph Goettlinger,José M. González-Navajas,Carl S. Goodyear,Andrea Gori,Jane L. Grogan,Daryl Grummitt,Andreas Grützkau,Claudia Haftmann,Jonas Hahn,Hamida Hammad,Günter J. Hämmerling,Leo Hansmann,Göran K. Hansson,Christopher M. Harpur,Susanne Hartmann,Andrea Hauser,Anja E. Hauser,David L. Haviland,David W. Hedley,Daniela C. Hernández,Guadalupe Herrera,Martin Herrmann,Christoph Hess,Christoph Hess,Thomas Höfer,Petra Hoffmann,Kristin A. Hogquist,Tristan Holland,Thomas Höllt,Thomas Höllt,Rikard Holmdahl,Pleun Hombrink,Jessica P. Houston,Bimba F. Hoyer,Bo Huang,Fang-Ping Huang,Johanna Huber,Jochen Huehn,Michael Hundemer,Christopher A. Hunter,William Hwang,William Hwang,Anna Iannone,Florian Ingelfinger,Sabine Ivison,Hans-Martin Jäck,Peter K. Jani,Beatriz Jávega,Stipan Jonjić,Toralf Kaiser,Tomas Kalina,Thomas Kamradt,Stefan H. E. Kaufmann,Baerbel Keller,Steven L. C. Ketelaars,Ahad Khalilnezhad,Ahad Khalilnezhad,Srijit Khan,Jan Kisielow,Paul Klenerman,Jasmin Knopf,Hui-Fern Koay,Katja Kobow,Jay K. Kolls,Wan Ting Kong,Manfred Kopf,Thomas Korn,Katharina Kriegsmann,Hendy Kristyanto,Thomas Kroneis,Andreas Krueger,J. Kühne,Christian Kukat,Désirée Kunkel,Heike Kunze-Schumacher,Tomohiro Kurosaki,Christian Kurts,Pia Kvistborg,Immanuel Kwok,Immanuel Kwok,Jonathan J M Landry,Olivier Lantz,Paola Lanuti,Francesca LaRosa,Agnès Lehuen,Salomé LeibundGut-Landmann,Michael D. Leipold,Leslie Y. T. Leung,Megan K. Levings,Andreia C. Lino,Francesco Liotta,Virginia Litwin,Yanling Liu,Hans-Gustaf Ljunggren,Michael Lohoff,Giovanna Lombardi,Lilly Lopez,Miguel López-Botet,Amy E. Lovett-Racke,Erik Lubberts,Hervé Luche,Burkhard Ludewig,Enrico Lugli,Sebastian Lunemann,Holden T. Maecker,Laura Maggi,Orla Maguire,Florian Mair,Kerstin H. Mair,Alberto Mantovani,Rudolf A. Manz,Aaron J. Marshall,Alicia Martínez-Romero,Gloria Martrus,Ivana Marventano,Wlodzimierz Maslinski,Giuseppe Matarese,Anna Vittoria Mattioli,Christian Maueröder,Christian Maueröder,Alessio Mazzoni,James McCluskey,Mairi McGrath,Helen M. McGuire,Iain B. McInnes,Henrik E. Mei,Fritz Melchers,Susanne Melzer,Dirk Mielenz,Stephen D. Miller,Kingston H. G. Mills,Hans Minderman,Jenny Mjösberg,Jenny Mjösberg,Jonni S. Moore,Barry Moran,Lorenzo Moretta,Tim R. Mosmann,Susann Müller,Gabriele Multhoff,Luis E. Muñoz,Christian Münz,Toshinori Nakayama,Milena Nasi,Katrin Neumann,Lai Guan Ng,Antonia Niedobitek,Sussan Nourshargh,Gabriel Núñez,José-Enrique O'Connor,A Ochel,Anna E. Oja,Diana Ordonez,Alberto Orfao,Eva Orlowski-Oliver,Wenjun Ouyang,Annette Oxenius,Raghavendra Palankar,Isabel Panse,Kovit Pattanapanyasat,Malte Paulsen,Dinko Pavlinic,Livius Penter,Pärt Peterson,Christian Peth,Jordi Petriz,Federica Piancone,Winfried F. Pickl,Silvia Piconese,Marcello Pinti,A. Graham Pockley,Malgorzata J. Podolska,Zhiyong Poon,Katharina Pracht,Immo Prinz,Carlo Pucillo,Sally A. Quataert,Linda Quatrini,Kylie M. Quinn,Kylie M. Quinn,Helena Radbruch,Tim R. Radstake,Susann Rahmig,Hans-Peter Rahn,Bartek Rajwa,Gevitha Ravichandran,Yotam Raz,Jonathan Rebhahn,Diether J. Recktenwald,Dorothea Reimer,Caetano Reis e Sousa,Ester B. M. Remmerswaal,Lisa Richter,Laura G. Rico,Andy Riddell,Aja M. Rieger,J. Paul Robinson,Chiara Romagnani,Anna Rubartelli,Jürgen Ruland,Armin Saalmüller,Yvan Saeys,Takashi Saito,Shimon Sakaguchi,Francisco Sala-de-Oyanguren,Yvonne Samstag,Sharon Sanderson,Inga Sandrock,Angela Santoni,Ramon Bellmas Sanz,Marina Saresella,Catherine Sautès-Fridman,Birgit Sawitzki,Linda Schadt,Alexander Scheffold,Hans Scherer,Matthias Schiemann,Frank A. Schildberg,Esther Schimisky,Andreas Schlitzer,Josephine Schlosser,S Schmid,Steffen Schmitt,Kilian Schober,Daniel Schraivogel,Wolfgang Schuh,Thomas Schüler,Reiner Schulte,Axel Schulz,Sebastian R. Schulz,Cristiano Scottà,Daniel Scott-Algara,David P. Sester,T. Vincent Shankey,Bruno Silva-Santos,Anna Katharina Simon,Katarzyna M. Sitnik,Silvano Sozzani,Daniel E. Speiser,Josef Spidlen,Anders Ståhlberg,Alan M. Stall,Natalie Stanley,Regina Stark,Christina Stehle,Tobit Steinmetz,Hannes Stockinger,Yousuke Takahama,Kiyoshi Takeda,Leonard Tan,Leonard Tan,Attila Tárnok,Attila Tárnok,Attila Tárnok,Gisa Tiegs,Gergely Toldi,Julia Tornack,Elisabetta Traggiai,Mohamed Trebak,Timothy Tree,Timothy Tree,Joe Trotter,John Trowsdale,Maria Tsoumakidou,Henning Ulrich,Sophia Urbanczyk,Willem van de Veen,Maries van den Broek,Edwin van der Pol,Sofie Van Gassen,Gert Van Isterdael,René A. W. van Lier,Marc Veldhoen,Salvador Vento-Asturias,Paulo Vieira,David Voehringer,Hans-Dieter Volk,Anouk von Borstel,Konrad von Volkmann,Ari Waisman,Rachael C. Walker,Paul K. Wallace,Sa A. Wang,Xin M. Wang,Michael D. Ward,Kirsten A. Ward-Hartstonge,Klaus Warnatz,Gary Warnes,Sarah Warth,Claudia Waskow,Claudia Waskow,James V. Watson,Carsten Watzl,Leonie Wegener,Thomas Weisenburger,Annika Wiedemann,Jürgen Wienands,Anneke Wilharm,Robert J. Wilkinson,Robert J. Wilkinson,Robert J. Wilkinson,Gerald Willimsky,James B. Wing,Rieke Winkelmann,Thomas Winkler,Oliver F. Wirz,Alicia Wong,Peter Wurst,Jennie H M Yang,Jennie H M Yang,Juhao Yang,Maria Yazdanbakhsh,Liping Yu,Alice Yue,Hanlin Zhang,Yi Zhao,Susanne Ziegler,Christina E. Zielinski,Jakob Zimmermann,Arturo Zychlinsky +462 more
TL;DR: These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community providing the theory and key practical aspects offlow cytometry enabling immunologists to avoid the common errors that often undermine immunological data.
Journal ArticleDOI
Expansion of a unique CD57+NKG2Chi natural killer cell subset during acute human cytomegalovirus infection
Sandra López-Vergès,Jeffrey M. Milush,Brian S. Schwartz,Marcelo J. Pando,Jessica Jarjoura,Vanessa A. York,Jeffrey P. Houchins,Steve Miller,Sang-Mo Kang,Phillip J. Norris,Douglas F. Nixon,Lewis L. Lanier +11 more
TL;DR: The preferential expansion of a unique subset of NK cells coexpressing the activating CD94–NKG2C receptor and CD57 in CMV+ donors is demonstrated and it is proposed that CD57 might provide a marker of “memory” NK cells that have been expanded in response to infection.
Journal ArticleDOI
CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset
Sandra López-Vergès,Jeffrey M. Milush,Suchitra Pandey,Vanessa A. York,Janice Arakawa-Hoyt,Hanspeter Pircher,Phillip J. Norris,Phillip J. Norris,Douglas F. Nixon,Lewis L. Lanier +9 more
TL;DR: A combination of a mature phenotype, a higher cytotoxic capacity, aHigher sensitivity to stimulation via CD16, with a decreased responsiveness to cytokines, and a decreased capacity to proliferate suggest that CD57(+) NK cells are highly mature and might be terminally differentiated.
Journal ArticleDOI
Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function.
Heinrich Schlums,Frank Cichocki,Frank Cichocki,Bianca Tesi,Jakob Theorell,Vivien Béziat,Tim D. Holmes,Hongya Han,Samuel C. C. Chiang,Bree Foley,Kristin Mattsson,Stella Larsson,Marie Schaffer,Karl-Johan Malmberg,Karl-Johan Malmberg,Karl-Johan Malmberg,Hans-Gustaf Ljunggren,Jeffrey S. Miller,Yenan T. Bryceson,Yenan T. Bryceson +19 more
TL;DR: The emergence of diverse subsets of human NK cells selectively lacking expression of signaling proteins after human cytomegalovirus (HCMV) infection is described, uncovering a spectrum of epigenetically unique adaptive NK cell subsets that diversify in response to viral infection and have distinct functional capabilities compared to canonical NK cells.
Journal ArticleDOI
Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C natural killer cells with potent function
Bree Foley,Sarah Cooley,Michael R. Verneris,Michelle Pitt,Julie M. Curtsinger,Xianghua Luo,Sandra López-Vergès,Lewis L. Lanier,Daniel J. Weisdorf,Jeffrey S. Miller +9 more
TL;DR: The kinetics of the NK-cell response to CMV reactivation in human recipients after hematopoietic cell transplantation is characterized to support the emerging concept that CMV-induced innate memory-cell populations may contribute to malignant disease relapse protection and infectious disease control long after transplantation.
References
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Journal ArticleDOI
Functions of natural killer cells
Eric Vivier,Elena Tomasello,Elena Tomasello,Myriam Baratin,Myriam Baratin,Thierry Walzer,Thierry Walzer,Sophie Ugolini,Sophie Ugolini +8 more
TL;DR: Although NK cells might appear to be redundant in several conditions of immune challenge in humans, NK cell manipulation seems to hold promise in efforts to improve hematopoietic and solid organ transplantation, promote antitumor immunotherapy and control inflammatory and autoimmune disorders.
Journal ArticleDOI
Nk cell recognition
TL;DR: The structure, function, and ligand specificity of the receptors responsible for NK cell recognition are reviewed and the role of EMT inNK cell recognition is reviewed.
Journal ArticleDOI
Adaptive immune features of natural killer cells
TL;DR: A mouse model of cytomegalovirus infection is used to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100-fold in the spleen and 1,000- fold in the liver after infection.
Journal ArticleDOI
Human natural killer cells: a unique innate immunoregulatory role for the CD56bright subset
Megan A. Cooper,Todd A. Fehniger,Sarah C. Turner,Kenneth S. Chen,Bobak A. Ghaheri,Tariq Ghayur,William E. Carson,Michael A. Caligiuri +7 more
TL;DR: It is proposed that human CD56bright NK cells have a unique functional role in the innate immune response as the primary source of NK cell–derived immunoregulatory cytokines, regulated in part by differential monokine production.
Journal ArticleDOI
Licensing of natural killer cells by host major histocompatibility complex class I molecules
Sung Jin Kim,Jennifer Poursine-Laurent,Steven M. Truscott,Lonnie Lybarger,Yun Jeong Song,Liping Yang,Anthony R. French,John B. Sunwoo,Suzanne Lemieux,Ted H. Hansen,Wayne M. Yokoyama +10 more
TL;DR: It is demonstrated that NK cells acquire functional competence through ‘licensing’ by self-MHC molecules, which results in two types of self-tolerant NK cells—licensed or unlicensed—and may provide new insights for exploiting NK cells in immunotherapy.