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Andreas Wietzorrek
Researcher at Norwich Research Park
Publications - 5
Citations - 3531
Andreas Wietzorrek is an academic researcher from Norwich Research Park. The author has contributed to research in topics: Streptomyces coelicolor & Gene. The author has an hindex of 5, co-authored 5 publications receiving 3335 citations.
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Journal ArticleDOI
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
Stephen D. Bentley,Keith F. Chater,Ana Cerdeño-Tárraga,Gregory L. Challis,Gregory L. Challis,Nicholas R. Thomson,Keith D. James,David Harris,Michael A. Quail,H. M. Kieser,D. Harper,Alex Bateman,Steve D.M. Brown,Govind Chandra,Carton W. Chen,Mark O. Collins,Ann Cronin,Andrew G. Fraser,Arlette Goble,J. Hidalgo,T. Hornsby,S. Howarth,Chih-Hung Huang,Tobias Kieser,L. Larke,Lee Murphy,Karen Oliver,Susan O'Neil,Ester Rabbinowitsch,Marie-Adèle Rajandream,Kim Rutherford,Simon Rutter,Kathy Seeger,David L. Saunders,Sarah Sharp,R. Squares,S. Squares,K. Taylor,T. Warren,Andreas Wietzorrek,John Woodward,Bart Barrell,Julian Parkhill,David A. Hopwood +43 more
TL;DR: The 8,667,507 base pair linear chromosome of Streptomyces coelicolor is reported, containing the largest number of genes so far discovered in a bacterium.
Journal ArticleDOI
A novel family of proteins that regulates antibiotic production in streptomycetes appears to contain an OmpR-like DNA-binding fold.
Journal ArticleDOI
Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor
Sean O'Rourke,Andreas Wietzorrek,Kay Fowler,Christophe Corre,Greg L. Challis,Keith F. Chater +5 more
TL;DR: Genetic evidence suggests that these two genes encode components of a hetero‐oligomeric repressor of MMF and Mm biosynthesis, which is shown to account for the ability of certain Mm non‐producing mutants to act as ‘secretors’ in cosynthesis with other ‘convertor’ mutants.
Journal ArticleDOI
The border sequence of the balhimycin biosynthesis gene cluster from Amycolatopsis balhimycina contains bbr, encoding a StrR-like pathway-specific regulator.
Riham M. Shawky,Oliver Puk,Andreas Wietzorrek,Stefan Pelzer,Eriko Takano,Wolfgang Wohlleben,Efthimia Stegmann +6 more
TL;DR: The newly identified StrR-like pathway-specific regulator, Bbr, was characterized to be a DNA-binding protein and may have a role in balhimycin biosynthesis.
Journal ArticleDOI
A single amino acid substitution in region 1.2 of the principal σ factor of Streptomyces coelicolor A3(2) results in pleiotropic loss of antibiotic production
TL;DR: Clones encoding the principal and essential σ factor of S. coelicolor restored Act and Red production in the afsB mutant BH5, indicating that loss of antibiotic production was not a result of the deficiency in SCB1 synthesis.