S
Stefan Pelzer
Researcher at University of Tübingen
Publications - 68
Citations - 3017
Stefan Pelzer is an academic researcher from University of Tübingen. The author has contributed to research in topics: Gene & Gene cluster. The author has an hindex of 31, co-authored 63 publications receiving 2878 citations.
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Journal ArticleDOI
Identification and Analysis of the Balhimycin Biosynthetic Gene Cluster and Its Use for Manipulating Glycopeptide Biosynthesis in Amycolatopsis mediterranei DSM5908
Stefan Pelzer,Roderich Süßmuth,Dorothee Heckmann,J. Recktenwald,Petra Huber,Guenther Jung,Wolfgang Wohlleben +6 more
TL;DR: Structural analysis by high-performance liquid chromatography–mass spectrometry, fragmentation studies, and amino acid analysis demonstrated that these oxygenases are involved in the coupling of the aromatic side chains of the unusual heptapeptide.
Journal ArticleDOI
Exploiting the genetic potential of polyketide producing streptomycetes.
TL;DR: An overview of the strategy for the identification and characterization of numerous biosynthesis gene clusters for polyketides displaying interesting functions and particular structural features is given.
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Crystal Structure of OxyB, a Cytochrome P450 Implicated in an Oxidative Phenol Coupling Reaction during Vancomycin Biosynthesis
Katja Zerbe,Olena Pylypenko,Francesca Vitali,Weiwen Zhang,Severine Rouset,Markus Heck,Jan Wim Vrijbloed,Daniel Bischoff,Bojan Bister,Roderich D. Süssmuth,Stefan Pelzer,Wolfgang Wohlleben,John A. Robinson,Ilme Schlichting +13 more
TL;DR: Gene-inactivation studies point to the involvement of OxyB in catalyzing the first oxidative phenol coupling reaction during glycopeptide antibiotic biosynthesis, and OxyB exhibits the typical P450-fold.
Journal ArticleDOI
A polyketide synthase in glycopeptide biosynthesis: the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine.
Volker Pfeifer,Graeme J. Nicholson,Johannes Ries,J. Recktenwald,Alexandre Bezerra Schefer,Riham M. Shawky,Joachim Schröder,Wolfgang Wohlleben,Stefan Pelzer +8 more
TL;DR: In this paper, a reaction sequence for balhimycin-type antibiotic from Amycolatopsis mediterranei was proposed, which is both a possible product of a polyketide synthase reaction and a likely precursor of Dpg.
Journal ArticleDOI
Biosynthetic Gene Cluster of Simocyclinone, a Natural Multihybrid Antibiotic
Axel Trefzer,Stefan Pelzer,J. Schimana,Sigrid Stockert,C. Bihlmaier,H.-P. Fiedler,Katrin Welzel,Andreas Vente,Andreas Bechthold +8 more
TL;DR: Based on the putative function of the gene products, a model for simocyclinone D8 biosynthesis was proposed and it was indicated that indeed the sim gene cluster had been cloned.