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Andrew J. Lutkewitte
Researcher at Washington University in St. Louis
Publications - 20
Citations - 113
Andrew J. Lutkewitte is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Biology & Internal medicine. The author has an hindex of 4, co-authored 9 publications receiving 54 citations.
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Journal ArticleDOI
Regulation of Signaling and Metabolism by Lipin-mediated Phosphatidic Acid Phosphohydrolase Activity.
TL;DR: How lipin-mediated control of PA concentrations regulates metabolism and signaling in mammalian organisms is discussed.
Journal ArticleDOI
Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration.
Andrew J. Lutkewitte,George G. Schweitzer,Stefanie Kennon-McGill,Melissa M. Clemens,Laura P. James,Hartmut Jaeschke,Brian N. Finck,Mitchell R. McGill +7 more
Journal ArticleDOI
Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans.
Kim H.H. Liss,Andrew J. Lutkewitte,Terri A. Pietka,Brian N. Finck,Michael P Franczyk,Jun Yoshino,Samuel Klein,Angela M. Hall +7 more
TL;DR: It is shown that expression of the gene that encodes MGAT1 is robustly induced during adipocyte differentiation and that its expression is suppressed in fat of genetically-obese mice and metabolically-abnormal obese human subjects, suggesting that MGAT 1 activity may play a role in regulating basal adipocyte FFA retention.
Journal ArticleDOI
Hepatic monoacylglycerol acyltransferase 1 is induced by prolonged food deprivation to modulate the hepatic fasting response.
Andrew J. Lutkewitte,Kyle S. McCommis,George G. Schweitzer,Kari T. Chambers,Mark J. Graham,Lingjue Wang,Gary J. Patti,Angela M. Hall,Brian N. Finck +8 more
TL;DR: Mogat1 is a fasting-induced PPAR α target gene that may feed forward to regulate liver PPARα activity during food deprivation and is found to reduce hepatic MGAT activity and triglyceride content compared with fasted controls.
Journal ArticleDOI
Monoacylglycerol Acyltransferase 1 Knockdown Exacerbates Hepatic Ischemia/Reperfusion Injury in Mice With Hepatic Steatosis.
Kim H.H. Liss,Shelby E. Ek,Andrew J. Lutkewitte,Terri A. Pietka,Mai He,Priya Skaria,Eric Tycksen,Daniel Ferguson,Valerie Blanc,Mark J. Graham,Angela M. Hall,Mitchell R. McGill,Kyle S. McCommis,Brian N. Finck +13 more
TL;DR: Mogat1 knockdown in a mouse model of NAFLD exacerbates IRI and inflammation and prolongs injury resolution, suggesting that Mogat1 may be necessary for liver regeneration following IRI, and that targeting this metabolic enzyme will not be an effective treatment to reduce steatosis‐associated graft dysfunction or failure.