B
Brian N. Finck
Researcher at Washington University in St. Louis
Publications - 122
Citations - 7189
Brian N. Finck is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Peroxisome proliferator-activated receptor & Insulin resistance. The author has an hindex of 42, co-authored 120 publications receiving 5868 citations.
Papers
More filters
Journal ArticleDOI
PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis.
Teresa C. Leone,John J. Lehman,Brian N. Finck,Paul J. Schaeffer,Adam R. Wende,Sihem Boudina,Michael Courtois,David F. Wozniak,Nandakumar Sambandam,Carlos Bernal-Mizrachi,Zhouji Chen,John O. Holloszy,Denis M. Medeiros,Robert E. Schmidt,Jeffrey E. Saffitz,E. Dale Abel,Clay F. Semenkovich,Daniel P. Kelly +17 more
TL;DR: It is demonstrated that PGC-1α is necessary for appropriate adaptation to the metabolic and physiologic stressors of postnatal life.
Journal ArticleDOI
Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals
Elisa Fabbrini,Marina Cella,Steve A. Mccartney,Anja Fuchs,Nada A. Abumrad,Terri A. Pietka,Zhouji Chen,Brian N. Finck,Dong Ho Han,Faidon Magkos,Caterina Conte,David Bradley,Gemma Fraterrigo,Gemma Fraterrigo,J. Christopher Eagon,Bruce W. Patterson,Marco Colonna,Samuel Klein +17 more
TL;DR: Adipose tissue from MAO individuals contains increased numbers of Th17 and Th22 cells, which produce cytokines that cause metabolic dysfunction in liver and muscle in vitro, which contributes to the pathogenesis of insulin resistance in obese people.
Journal ArticleDOI
Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis
Brian J. DeBosch,Monique R. Heitmeier,Allyson L. Mayer,Cassandra B. Higgins,Jan R. Crowley,Thomas E. Kraft,Maggie M.-Y. Chi,Elizabeth P. Newberry,Zhouji Chen,Brian N. Finck,Nicholas O. Davidson,Kevin E. Yarasheski,Paul W. Hruz,Kelle H. Moley +13 more
TL;DR: Trehalose-mediated inhibition of glucose transport induced AMPK (adenosine 5′-monophosphate–activated protein kinase)–dependent autophagy and regression of hepatic steatosis in vivo and a reduction in the accumulation of lipid droplets in primary murine hepatocyte cultures.
Journal ArticleDOI
The PPAR regulatory system in cardiac physiology and disease.
TL;DR: A review will summarize the findings and other recent studies regarding the effects of experimental PPAR activation and deactivation and its potential impact on cardiomyopathic remodeling.
Journal ArticleDOI
Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells
Wing Y. Lam,Amy M. Becker,Krista M. Kennerly,Rachel O.L. Wong,Jonathan D. Curtis,Elizabeth M. Llufrio,Kyle S. McCommis,Johannes F. Fahrmann,Hannah A. Pizzato,Ryan M. Nunley,Jieun Lee,Michael J. Wolfgang,Gary J. Patti,Brian N. Finck,Erika L. Pearce,Deepta Bhattacharya +15 more
TL;DR: Glucose uptake and mitochondrial pyruvate import prevent bioenergetic crises and allow LLPCs to persist and immunizations that maximize these plasma cell metabolic properties might thus provide enduring antibody-mediated immunity.