Andrew M. Riley

TL;DR: In this paper, the crystal structures of the wild-type PH domain and a gain-of-function mutant E41K in complex with D-myo -inositol 1,3,4,5-tetra-kisphosphate (Ins (1, 3, 4,5)P 4 ) were determined.

TL;DR: The use of cDNA phage libraries in conjunction with synthetic biotinylated derivatives of phosphatidylinositol 3,5-bisphosphate in the identification of a mammalian phosphate-binding protein, mVps24p, is reported, providing the first direct link between phosphate-based lipid found in eukaryotes and the protein machinery involved in the production of the class-E cellular phenotype.

TL;DR: The stereochemical requirements for binding and activation by inositol phosphates are elucidated, demonstrating that activation requires three adjacent phosphate groups and that other positions on the inositl ring can tolerate bulky substituents.

TL;DR: It is shown that FGF-2 induces Akt phosphorylation in HUVEC resulting in antiapoptotic effect in serum-deprived cells and increase in cellular motility, which definitively identify the Akt inhibitor Ins(1,3,4,5,6)P5 as a specific antiangiogenic and antitumor factor.

TL;DR: Reappraisal of the literature based on the new signal assignments revealed that neo- and d-chiro-IP6 occur widely in both terrestrial and aquatic ecosystems, and confirmed that the inositol phosphates can constitute a considerable fraction of the organic phosphorus in soils.