P
Pietro Fontana
Researcher at Harvard University
Publications - 18
Citations - 1031
Pietro Fontana is an academic researcher from Harvard University. The author has contributed to research in topics: Inflammasome & Medicine. The author has an hindex of 8, co-authored 13 publications receiving 594 citations. Previous affiliations of Pietro Fontana include Boston Children's Hospital & University of Oxford.
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Journal ArticleDOI
Serine ADP-Ribosylation Depends on HPF1
Juan José Bonfiglio,Pietro Fontana,Qi Zhang,Thomas Colby,Ian Gibbs-Seymour,Ilian Atanassov,Edward Bartlett,Roko Zaja,Ivan Ahel,Ivan Matic +9 more
TL;DR: It is reported that serine ADPr is strictly dependent on histone PARylation factor 1 (HPF1), a recently identified regulator of PARP-1, and proposed that O-linked protein AD Pr is the key signal in PARP/PARP-2-dependent processes that govern genome stability.
Journal ArticleDOI
HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity.
TL;DR: The identification of histone PARylation factor 1 (HPF1) as a regulator of ADP-ribosylation signaling in the DNA damage response is reported and it is suggested that HPF1 functions at the crossroads of Histone ADp-riboylation and PARP-1 automodification.
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HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation
Marcin J. Suskiewicz,Florian Zobel,Tom E. H. Ogden,Pietro Fontana,Antonio Ariza,Ji-Chun Yang,Kang Zhu,Lily Bracken,William Hawthorne,Dragana Ahel,David Neuhaus,Ivan Ahel +11 more
TL;DR: Assembly of a catalytic centre formed by HPF1 bound to PARP1 or PARP2 is essential for protein ADP-ribosylation after DNA damage in human cells.
Journal ArticleDOI
Serine ADP-ribosylation reversal by the hydrolase ARH3
TL;DR: This work found by quantitative proteomics that histone Ser-ADPr is reversible in cells during response to DNA damage, and identified ARH3/ADPRHL2 as capable of efficiently and specifically removing Ser- ADPr of histones and other proteins.
Journal ArticleDOI
DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation
L. Robert Hollingsworth,L. Robert Hollingsworth,Humayun Sharif,Humayun Sharif,Andrew R. Griswold,Andrew R. Griswold,Pietro Fontana,Pietro Fontana,Julian Mintseris,Kevin B. Dagbay,Kevin B. Dagbay,Joao A. Paulo,Steven P. Gygi,Daniel A. Bachovchin,Daniel A. Bachovchin,Hao Wu,Hao Wu +16 more
TL;DR: In this paper, a ternary complex consisting of DPP9, full-length NLRP1, and the NLRPTCT was found to be a checkpoint for inflammasome activation.