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Andrew S J Marshall
Researcher at University of Oxford
Publications - 23
Citations - 2556
Andrew S J Marshall is an academic researcher from University of Oxford. The author has contributed to research in topics: Medicine & Receptor. The author has an hindex of 9, co-authored 13 publications receiving 2241 citations. Previous affiliations of Andrew S J Marshall include Boston Children's Hospital.
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Journal ArticleDOI
Dectin-1 Mediates the Biological Effects of β-Glucans
Gordon D. Brown,Jurgen Herre,David L. Williams,Janet A. Willment,Andrew S J Marshall,Siamon Gordon +5 more
TL;DR: It is shown that Dectin-1 mediates the production of TNF-α in response to zymosan and live fungal pathogens, an activity that occurs at the cell surface and requires the cytoplasmic tail and immunoreceptor tyrosine activation motif of Dect in addition to Toll-like receptor (TLR)-2 and Myd88.
Journal ArticleDOI
Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages
Jurgen Herre,Andrew S J Marshall,Emmanuelle Caron,Alexander D. Edwards,David L. Williams,Edina Schweighoffer,Victor L. J. Tybulewicz,Caetano Reis e Sousa,Siamon Gordon,Gordon D. Brown +9 more
TL;DR: Dectin-1, a proinflammatory nonopsonic receptor for beta-glucans, is examined, and it is shown that it mediates the internalization of beta- glucan-bearing ligands, including yeast particles.
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The human β‐glucan receptor is widely expressed and functionally equivalent to murine Dectin‐1 on primary cells
Janet A. Willment,Andrew S J Marshall,Delyth M. Reid,David L. Williams,Simon Y. C. Wong,Siamon Gordon,Gordon D. Brown,Gordon D. Brown +7 more
TL;DR: It is demonstrated that human Dectin‐1, the β‐glucan receptor (βGR), is widely expressed and present on all monocyte populations as well as macrophages, DC, neutrophils and eosinophils, and that this receptor is not myeloid restricted.
Journal ArticleDOI
Structure of the Fungal Beta-Glucan-Binding Immune Receptor Dectin-1: Implications for Function.
James Brown,Christopher A. O’Callaghan,Andrew S J Marshall,Robert J.C. Gilbert,Christian Siebold,Siamon Gordon,Gordon D. Brown,E Y Jones +7 more
TL;DR: Several dectin‐1 crystal structures are reported, including a high‐resolution structure and a 2.8 Å resolution structure in which a short soaked natural β‐glucan is trapped in the crystal lattice, which suggest potential mechanisms of defense against fungal pathogens.
Journal ArticleDOI
Identification and Characterization of a Novel Human Myeloid Inhibitory C-type Lectin-like Receptor (MICL) That Is Predominantly Expressed on Granulocytes and Monocytes
Andrew S J Marshall,Janet A. Willment,Hsi-Hsien Lin,David L. Williams,Siamon Gordon,Gordon D. Brown +5 more
TL;DR: The identification and characterization of a novel myeloid inhibitory C-type lectin-like receptor (MICL) whose expression is primarily restricted to granulocytes and monocytes is reported, suggesting that MICL is a negative regulator of granulocyte and monocyte function.