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Andrzej Stepulak
Researcher at Medical University of Lublin
Publications - 104
Citations - 2697
Andrzej Stepulak is an academic researcher from Medical University of Lublin. The author has contributed to research in topics: Cancer & Cancer cell. The author has an hindex of 25, co-authored 94 publications receiving 2132 citations. Previous affiliations of Andrzej Stepulak include Åbo Akademi University & Humboldt State University.
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Journal ArticleDOI
Expression of glutamate receptor subunits in human cancers.
Andrzej Stepulak,Hella Luksch,Christine Gebhardt,Ortrud Uckermann,Jenny Marzahn,Marco Sifringer,Wojciech Rzeski,Christian Staufner,Katja S. Brocke,Lechoslaw Turski,Chrysanthy Ikonomidou +10 more
TL;DR: It is revealed that glutamate receptor subunits are differentially expressed in human tumor cell lines at the mRNA and the protein level, and that their expression is associated with the formation of functional channels.
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Mechanisms leading to disseminated apoptosis following NMDA receptor blockade in the developing rat brain
Henrik H. Hansen,Henrik H. Hansen,Tim Briem,Mark Dzietko,Marco Sifringer,Marco Sifringer,Alexander Voss,Alexander Voss,Wojciech Rzeski,Barbara Zdzisińska,Friederike Thor,Rolf Heumann,Andrzej Stepulak,Petra Bittigau,Petra Bittigau,Chrysanthy Ikonomidou,Chrysanthy Ikonomidou +16 more
TL;DR: It is shown that systemic administration of the NMDA receptor antagonist MK801 to 7-day-old rats leads to impaired activity of extracellular signal-regulated kinase 1/2 (ERK1/2) and reduces levels of phosphorylated cAMP-responsive element binding protein (CREB) in brain regions which display severe apoptotic neurodegeneration.
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Comprehensive Review on Betulin as a Potent Anticancer Agent
TL;DR: The anticancer and chemopreventive potential of BE in vitro and in vivo is summarized by carefully dissecting and comparing the doses and tumour lines used in previous studies, as well as focusing on mechanisms underlying its activity at cellular and molecular level, and discuss future prospects.
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Whole-tissue biopsy phenotyping of three-dimensional tumours reveals patterns of cancer heterogeneity
Nobuyuki Tanaka,Nobuyuki Tanaka,Shigeaki Kanatani,Raju Tomer,Cecilia Sahlgren,Cecilia Sahlgren,Pauliina Kronqvist,Dagmara Kaczynska,Lauri Louhivuori,Loránd L. Kis,Loránd L. Kis,Claes Lindh,Claes Lindh,Przemysław Mitura,Andrzej Stepulak,Sara Corvigno,Johan Hartman,Johan Hartman,Patrick Micke,Artur Mezheyeuski,Carina Strell,Joseph W. Carlson,Joseph W. Carlson,Carlos Fernández Moro,Hanna Dahlstrand,Hanna Dahlstrand,Hanna Dahlstrand,Arne Östman,Kazuhiro Matsumoto,Peter Wiklund,Mototsugu Oya,Ayako Miyakawa,Karl Deisseroth,Karl Deisseroth,Per Uhlén +34 more
TL;DR: It is shown that three-dimensional light-sheet microscopy of cleared solid tumours can identify unique patterns of phenotypic heterogeneity, in the epithelial-to-mesenchymal transition and in angiogenesis, at single-cell resolution in whole formalin-fixed paraffin-embedded (FFPE) biopsy samples.
Journal ArticleDOI
NMDA antagonist inhibits the extracellular signal-regulated kinase pathway and suppresses cancer growth
Andrzej Stepulak,Marco Sifringer,Wojciech Rzeski,Stefanie Endesfelder,Alexander Gratopp,Elena E. Pohl,Petra Bittigau,Ursula Felderhoff-Mueser,Angela M. Kaindl,Christoph Bührer,Henrik H. Hansen,Marta Stryjecka-Zimmer,Lechoslaw Turski,Chrysanthy Ikonomidou +13 more
TL;DR: Dizocilpine inhibits the extracellular signal-regulated kinase 1/2 pathway, an intracellular signaling cascade that is activated by growth factors and controls the proliferation of cancer cells, and indicates that it may be useful in the therapy of human cancers.