H
Hella Luksch
Researcher at Dresden University of Technology
Publications - 29
Citations - 903
Hella Luksch is an academic researcher from Dresden University of Technology. The author has contributed to research in topics: Proinflammatory cytokine & Sting. The author has an hindex of 14, co-authored 24 publications receiving 706 citations. Previous affiliations of Hella Luksch include Boston Children's Hospital.
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Journal ArticleDOI
Expression of glutamate receptor subunits in human cancers.
Andrzej Stepulak,Hella Luksch,Christine Gebhardt,Ortrud Uckermann,Jenny Marzahn,Marco Sifringer,Wojciech Rzeski,Christian Staufner,Katja S. Brocke,Lechoslaw Turski,Chrysanthy Ikonomidou +10 more
TL;DR: It is revealed that glutamate receptor subunits are differentially expressed in human tumor cell lines at the mRNA and the protein level, and that their expression is associated with the formation of functional channels.
Journal ArticleDOI
SAMHD1 prevents autoimmunity by maintaining genome stability
Stefanie Kretschmer,Christine Wolf,N. König,Wolfgang Staroske,Jochen Guck,Jochen Guck,Martin Häusler,Hella Luksch,Laura A. Nguyen,Baek Kim,Baek Kim,Dimitra Alexopoulou,Andreas Dahl,Alexander Rapp,M. Cristina Cardoso,Anna Shevchenko,Min Ae Lee-Kirsch +16 more
TL;DR: It is shown that increased dNTP pools due to SAMHD1 deficiency cause genome instability in fibroblasts of patients with AGS, establishing a novel link between DNA damage signalling and innate immune activation in the pathogenesis of autoimmunity.
Journal ArticleDOI
STING-associated lung disease in mice relies on T cells but not type I interferon
Hella Luksch,W. Alexander Stinson,Derek J. Platt,Wei Qian,Gowri Kalugotla,Cathrine A. Miner,Brock G. Bennion,Alexander Gerbaulet,Angela Rösen-Wolff,Jonathan J. Miner +9 more
TL;DR: Bone marrow transplantation revealed that certain features of STING N153S-associated disease are intrinsic to the hematopoietic compartment and develops independently of type I interferon signaling and cGAS.
Journal ArticleDOI
Glutamate receptors in pediatric tumors of the central nervous system.
Katja S. Brocke,Christian Staufner,Hella Luksch,Kathrin D. Geiger,Andrzej Stepulak,Jenny Marzahn,Gabriele Schackert,Achim Temme,Chrysanthy Ikonomidou +8 more
TL;DR: Examination of expression of glutamate receptor subunits in pediatric CNS tumors suggests that adjunctive treatment with glutamate receptor modulators may be a feasible therapeutic option for pediatric patients with CNS tumors.
Journal Article
Silencing of selected glutamate receptor subunits modulates cancer growth.
Hella Luksch,Ortrud Uckermann,Andrzej Stepulak,Sandy Hendruschk,Jenny Marzahn,Susanne Bastian,Christian Staufner,Achim Temme,Chrysanthy Ikonomidou +8 more
TL;DR: The findings suggest that glutamate receptor subunits on cancer cells are linked to biochemical pathways that regulate malignant phenotype.