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Anele Waters
Researcher at King's College London
Publications - 27
Citations - 4352
Anele Waters is an academic researcher from King's College London. The author has contributed to research in topics: Cytotoxic T cell & Medicine. The author has an hindex of 13, co-authored 18 publications receiving 3979 citations. Previous affiliations of Anele Waters include National Health Service & Middlesex University.
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Journal ArticleDOI
Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections.
Victor Appay,P. Rod Dunbar,Margaret F. C. Callan,Paul Klenerman,Geraldine M. Gillespie,Laura Papagno,Graham S. Ogg,Abigail S. King,Franziska Lechner,Celsa A. Spina,Susan J. Little,Diane V. Havlir,Douglas D. Richman,Norbert H. Gruener,Gerd R. Pape,Anele Waters,Philippa Easterbrook,Mariolina Salio,Vincenzo Cerundolo,Andrew J. McMichael,Sarah Rowland-Jones +20 more
TL;DR: There are significant enrichments at different stages of cellular differentiation in the chronic phase of persistent infection according to the viral specificity, which suggests that distinct memory T-cell populations are established in different virus infections.
Journal ArticleDOI
HIV-Specific Cd8+T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function
Victor Appay,Douglas F. Nixon,Sean M. Donahoe,Geraldine M. Gillespie,Tao Dong,Abigail S. King,Graham S. Ogg,Hans M. L. Spiegel,Christopher P. Conlon,Celsa A. Spina,Celsa A. Spina,Diane V. Havlir,Douglas D. Richman,Douglas D. Richman,Anele Waters,Philippa J. Easterbrook,Andrew J. McMichael,Sarah Rowland-Jones +17 more
TL;DR: The majority of circulating CD8+ T cells specific for CMV and HIV antigens are functionally active with regards to the secretion of antiviral cytokines in response to antigen, although a subset of tetramer-staining cells was identified that secretes IFN-γ and MIP-1β but not TNF-α.
Journal ArticleDOI
Characterization of CD4(+) CTLs ex vivo.
Victor Appay,John Zaunders,Laura Papagno,Julian Sutton,Angel B. Jaramillo,Anele Waters,Philippa Easterbrook,Pat Grey,Don Smith,Andrew J. McMichael,David A. Cooper,Sarah Rowland-Jones,Anthony D. Kelleher +12 more
TL;DR: Ex vivo analysis shows that a population of CD4+ perforin+ T cells is present in the circulation at low numbers in healthy donors and is markedly expanded in donors with chronic viral infections, in particular HIV infection, at all stages of the disease, including early primary infection.
Journal ArticleDOI
Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection
Laura Papagno,Celsa A. Spina,Arnaud Marchant,Mariolina Salio,Nathalie Rufer,Susan J. Little,Tao Dong,G Chesney,Anele Waters,Philippa Easterbrook,P R Dunbar,Dawn Shepherd,Vincenzo Cerundolo,Vincent C. Emery,Paul D. Griffiths,Christopher P. Conlon,Andrew J. McMichael,Douglas D. Richman,Sarah Rowland-Jones,Victor Appay +19 more
TL;DR: It is shown that the activation level and the differentiation state of T-cells are closely related and may be part of the mechanism through which HIV-1-mediated immune activation exhausts the capacity of the immune system.
Journal ArticleDOI
Presence of HIV-1 Gag-specific IFN-gamma+IL-2+ and CD28+IL-2+ CD4 T cell responses is associated with nonprogression in HIV-1 infection.
TL;DR: The number/function of Gag p24-specific CD4 T cells in HIV-infected long-term nonprogressors (LTNPs) and those of 16 slow progressors (SPs), also HIV infected for a median of 14 years but whose CD4 count had declined to <500 cells/μl, correlated inversely with virus load.