S
Sarah J. Campbell
Researcher at Wellcome Trust Centre for Human Genetics
Publications - 13
Citations - 3268
Sarah J. Campbell is an academic researcher from Wellcome Trust Centre for Human Genetics. The author has contributed to research in topics: Tuberculosis & Genotype. The author has an hindex of 13, co-authored 13 publications receiving 3106 citations.
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Journal ArticleDOI
Detecting recent positive selection in the human genome from haplotype structure
Pardis C. Sabeti,David Reich,John M. Higgins,Haninah Z P Levine,Daniel J. Richter,Stephen F. Schaffner,Stacey Gabriel,Jill Platko,Nick Patterson,Gavin J. McDonald,Hans Ackerman,Sarah J. Campbell,David Altshuler,David Altshuler,Richard H. Cooper,Dominic P. Kwiatkowski,Ryk Ward,Eric S. Lander +17 more
TL;DR: A framework for detecting the genetic imprint of recent positive selection by analysing long-range haplotypes in human populations is introduced, and the core haplotypes carrying the proposed protective mutation stand out and show significant evidence of selection.
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A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis.
Chiea Chuen Khor,Stephen J Chapman,Stephen J Chapman,Fredrik O. Vannberg,Aisling Dunne,Caroline Murphy,Edmund Y. S. Ling,Angela J. Frodsham,Andrew Walley,Andrew Walley,Otto Kyrieleis,Amir R. Khan,Christophe Aucan,Shelley Segal,Catrin E. Moore,Kyle Knox,Sarah J. Campbell,Christian Lienhardt,Anthony Scott,Peter Aaby,Oumou Sow,Robert T Grignani,Robert T Grignani,Jackson Sillah,Giorgio Sirugo,N Peshu,Thomas N. Williams,Kathryn Maitland,Robert J. O. Davies,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Nicholas P. J. Day,Djamel Yala,Derrick W. Crook,Kevin Marsh,James A. Berkley,Luke A. J. O'Neill,Adrian V. S. Hill +38 more
TL;DR: In this paper, a case-control study of 6,106 individuals from the UK, Vietnam and several African countries with invasive pneumococcal disease, bacteremia, malaria and tuberculosis was conducted.
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Association of a Polymorphism in the P2X7 Gene with Tuberculosis in a Gambian Population
Cheuk M. Li,Cheuk M. Li,Sarah J. Campbell,Dinakantha S. Kumararatne,Richard Bellamy,Cyril Ruwende,Keith P. W. J. McAdam,Adrian V. S. Hill,David A. Lammas +8 more
TL;DR: A significant protective association against tuberculosis was found for 1 promoter SNP, at nucleotide position -762, which supports a role for ATP/P2X(7)-mediated host regulation of Mycobacterium tuberculosis infection.
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Vitamin D Receptor Polymorphisms and Susceptibility to Tuberculosis in West Africa: A Case-Control and Family Study
Liza Bornman,Sarah J. Campbell,Katherine Fielding,Boubacar Bah,Jackson Sillah,Per Gustafson,Kebba Manneh,Ida Lisse,Angela Allen,Giorgio Sirugo,Aissatou Sylla,Peter Aaby,Keith P. W. J. McAdam,Oumou Bah-Sow,Steve Bennett,Christian Lienhardt,Adrian V. S. Hill +16 more
TL;DR: The significance of the family-based associations found between TB and FokI-BsmI-ApaI-TaqI and the FA haplotype supports a role for VDR haplotypes, rather than individual genotypes, in susceptibility to TB.
Journal ArticleDOI
Polymorphism within the interferon-gamma/receptor complex is associated with pulmonary tuberculosis.
Graham S Cooke,Sarah J. Campbell,Jackson Sillah,Per Gustafson,Boubacar Bah,Georgio Sirugo,Steve Bennett,Keith P. W. J. McAdam,Oumou Sow,Christian Lienhardt,Adrian V. S. Hill +10 more
TL;DR: Evidence of a significant role for genetic variation at the IFNG locus is provided and the hypothesis that genetically determined variation in both IFN-gamma production and responsiveness influences the risk of developing tuberculosis is supported.