A
Angela Marcobal
Researcher at Stanford University
Publications - 20
Citations - 2965
Angela Marcobal is an academic researcher from Stanford University. The author has contributed to research in topics: Gut flora & Microbiome. The author has an hindex of 15, co-authored 20 publications receiving 2433 citations. Previous affiliations of Angela Marcobal include University of California, Davis.
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Journal ArticleDOI
Consumption of human milk oligosaccharides by gut-related microbes.
Angela Marcobal,Mariana Barboza,John W. Froehlich,David E. Block,J. Bruce German,Carlito B. Lebrilla,David A. Mills +6 more
TL;DR: This work examined 16 bacterial strains belonging to 10 different genera for growth on human milk oligosaccharides, revealing bacteroides as avid consumers of this substrate, and provides insight on how human Milk oligosACcharides shape the infant intestinal microbiota.
Journal ArticleDOI
Bacteroides in the Infant Gut Consume Milk Oligosaccharides via Mucus-Utilization Pathways
Angela Marcobal,Mariana Barboza,Erica D. Sonnenburg,Nicholas A. Pudlo,Eric C. Martens,Prerak T. Desai,Carlito B. Lebrilla,Bart C. Weimer,David A. Mills,J. Bruce German,Justin L. Sonnenburg +10 more
TL;DR: It is determined that the prominent neonate gut residents, Bacteroides thetaiotaomicron and Bactroides fragilis, induce the same genes during HMO consumption that are used to harvest host mucus glycans, which are structurally similar to HMOs.
Journal ArticleDOI
Complex Interactions Among Diet, Gastrointestinal Transit, and Gut Microbiota in Humanized Mice
Purna C. Kashyap,Purna C. Kashyap,Angela Marcobal,Luke K. Ursell,Muriel H. Larauche,Henri Duboc,Kristen A. Earle,Erica D. Sonnenburg,Jessica A. Ferreyra,Steven K. Higginbottom,Mulugeta Million,Yvette Taché,Pankaj J. Pasricha,Rob Knight,Rob Knight,Gianrico Farrugia,Justin L. Sonnenburg +16 more
TL;DR: Diet can affect GI transit through microbiota-dependent or microbiota-independent pathways, depending on the type of dietary change, and the effect of the microbiota on transit largely depends on the amount and type of polysaccharides present in the diet.
Journal ArticleDOI
A metabolomic view of how the human gut microbiota impacts the host metabolome using humanized and gnotobiotic mice
Angela Marcobal,Purna C. Kashyap,Purna C. Kashyap,Tyrrell A. Nelson,Pavel A. Aronov,Mohamed S. Donia,Alfred M. Spormann,Michael A. Fischbach,Justin L. Sonnenburg +8 more
TL;DR: It is shown that simplified communities can drive major changes in the host metabolomic profile, and is demonstrated that metabolomics constitutes a powerful avenue for functional characterization of the intestinal microbiota and its interaction with the host.
Journal ArticleDOI
Human milk oligosaccharide consumption by intestinal microbiota.
TL;DR: This work reviews proposed mechanisms for the depletion and metabolism of HMO by two major bacterial genera within the infant intestinal microbiota, Bifidobacterium and Bacteroides.