A
Angela O. Achieng
Researcher at United States Army Medical Research Unit-Kenya
Publications - 4
Citations - 55
Angela O. Achieng is an academic researcher from United States Army Medical Research Unit-Kenya. The author has contributed to research in topics: Artemether & Plasmodium falciparum. The author has an hindex of 3, co-authored 4 publications receiving 44 citations.
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Journal ArticleDOI
Temporal trends in prevalence of Plasmodium falciparum molecular markers selected for by artemether–lumefantrine treatment in pre-ACT and post-ACT parasites in western Kenya
Angela O. Achieng,Peninah Muiruri,Luicer A. Ingasia,Benjamin Opot,Dennis W. Juma,Redemptah Yeda,Bidii S. Ngalah,Bernhards Ogutu,Ben Andagalu,Hoseah M. Akala,Edwin Kamau +10 more
TL;DR: There is a significant change in parasite genotype, with key molecular determinants of AL selection almost reaching saturation, and there is need to closely monitor parasite genotypic, phenotypic and clinical dynamics in response to continued use of AL in western Kenya.
Journal ArticleDOI
Reduced in vitro doxycycline susceptibility in plasmodium falciparum field isolates from Kenya is associated with PfTetQ KYNNNN sequence polymorphism.
Angela O. Achieng,Luiser A. Ingasia,Dennis W. Juma,Agnes C. Cheruiyot,Charles Okudo,Redemptah Yeda,Jelagat Cheruiyot,Hoseah M. Akala,Jacob D. Johnson,Ben Andangalu,Fredrick Eyase,Walter G. Z. O. Jura,Edwin Kamau +12 more
TL;DR: PTetQ sequence polymorphism is associated with a reduced doxycycline susceptibility phenotype in Kenyan isolates and is a potential marker for susceptibility testing.
Journal ArticleDOI
Five-year tracking of Plasmodium falciparum allele frequencies in a holoendemic area with indistinct seasonal transitions.
Hoseah M. Akala,Angela O. Achieng,Fredrick Eyase,Dennis W. Juma,Luiser A. Ingasia,Agnes C. Cheruiyot,Charles Okello,Duke Omariba,Eunice A. Owiti,Catherine Muriuki,Redemptah Yeda,Ben Andagalu,Jacob D. Johnson,Edwin Kamau +13 more
TL;DR: In this article, the seasonal patterns of frequency of polymorphic variants of Plasmodium falciparum were analyzed for polymorphisms and parasitemia changes in the 53 months from March 2008 to August 2012.
Journal ArticleDOI
Case Report of Attenuated-Responsiveness to Coartem ® in Western Kenya
Edwin Kamau,Hoseah M. Akala,Angela O. Achieng,Redemptah Yeda,Luicer A. Ingasia,Agnes C. Cheruiyot,Dennis W. Juma,Charles Okudo,Duke Omariba,Catherine Muriuki,Eunice A. Owiti,Patrick Omondi,Amos Otedo,Ben Andagalu,Bernhards Ogutu +14 more
TL;DR: This report was the first showing declining responsiveness to artemisinin outside Southeast Asia and there is need for continued global surveillance to effectively manage emergence and spread of artemether-lumefantrine drug resistance which has now been found in Southeast Asia.