R
Redemptah Yeda
Researcher at Kenya Medical Research Institute
Publications - 25
Citations - 338
Redemptah Yeda is an academic researcher from Kenya Medical Research Institute. The author has contributed to research in topics: Malaria & Plasmodium falciparum. The author has an hindex of 9, co-authored 17 publications receiving 255 citations. Previous affiliations of Redemptah Yeda include United States Army Medical Research Unit-Kenya.
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Journal ArticleDOI
The role of Pfmdr1 and Pfcrt in changing chloroquine, amodiaquine, mefloquine and lumefantrine susceptibility in western-Kenya P. falciparum samples during 2008-2011.
Fredrick Eyase,Hoseah M. Akala,Luiser A. Ingasia,Agnes C. Cheruiyot,Angela A. Omondi,Charles Okudo,Dennis W. Juma,Redemptah Yeda,Ben Andagalu,Elizabeth Wanja,Edwin Kamau,David Schnabel,Wallace D. Bulimo,Norman C. Waters,Douglas S. Walsh,Jacob D. Johnson +15 more
TL;DR: A rapid but steady percent increase in wild-type parasites with regard to both Pfmdr1 and Pfcrt between 2008 and 2011 is observed, which may be due to releasing of drug pressure on the parasite from reduced use of AQ in the face of increased Artemisinin Combination Therapy (ACT) administration following the intervention of the Global Fund in 2008.
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Temporal trends in prevalence of Plasmodium falciparum molecular markers selected for by artemether–lumefantrine treatment in pre-ACT and post-ACT parasites in western Kenya
Angela O. Achieng,Peninah Muiruri,Luicer A. Ingasia,Benjamin Opot,Dennis W. Juma,Redemptah Yeda,Bidii S. Ngalah,Bernhards Ogutu,Ben Andagalu,Hoseah M. Akala,Edwin Kamau +10 more
TL;DR: There is a significant change in parasite genotype, with key molecular determinants of AL selection almost reaching saturation, and there is need to closely monitor parasite genotypic, phenotypic and clinical dynamics in response to continued use of AL in western Kenya.
Journal ArticleDOI
In vitro antiplasmodial activity of selected Luo and Kuria medicinal plants
Bethwell O. Owuor,James O. Ochanda,John O. Kokwaro,Agnes C. Cheruiyot,Redemptah Yeda,Charles Okudo,Hoseah M. Akala +6 more
TL;DR: Ethnobotanical knowledge was sufficiently reliable for identifying plant extracts with antiplasmodial activity in Kenya and this study seeking new antimalarials from medicinal plants is guided by ethnobotany.
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Analysis of major genome loci underlying artemisinin resistance and pfmdr1 copy number in pre- and post-ACTs in western Kenya.
Bidii S. Ngalah,Luiser A. Ingasia,Agnes C. Cheruiyot,Lorna J. Chebon,Lorna J. Chebon,Dennis W. Juma,Peninah Muiruri,Peninah Muiruri,Irene Onyango,Jack Ogony,Redemptah Yeda,Jelagat Cheruiyot,Emmanuel Mbuba,Grace Mwangoka,Angela O. Achieng,Angela O. Achieng,Zipporah Ng’ang’a,Ben Andagalu,Hoseah M. Akala,Edwin Kamau +19 more
TL;DR: Data showed SNPs on chromosome 13 and 14 had different frequency and trend in western Kenya parasites compared SEA, and suggests genetic signature of artemisinin resistance in Africa might be different from SEA.
Journal ArticleDOI
Polymorphisms in Pfmdr1, Pfcrt, and Pfnhe1 Genes Are Associated with Reduced In Vitro Activities of Quinine in Plasmodium falciparum Isolates from Western Kenya
Jelagat Cheruiyot,Luicer A. Ingasia,Angela A. Omondi,Angela A. Omondi,Dennis W. Juma,Benjamin Opot,J.M. Ndegwa,J.M. Ndegwa,Joan Mativo,Agnes C. Cheruiyot,Agnes C. Cheruiyot,Redemptah Yeda,Charles Okudo,Peninah Muiruri,Ngalah S. Bidii,Lorna J. Chebon,Paul Oyieng’ Ang’ienda,Fredrick Eyase,Jacob D. Johnson,Wallace D. Bulimo,Ben Andagalu,Hoseah M. Akala,Edwin Kamau +22 more
TL;DR: Clinical efficacy studies are now required to confirm the validity of these markers and the importance of parasite genetic background, and the mechanisms of action and resistance have not been fully elucidated.