J
Jelagat Cheruiyot
Researcher at Kenya Medical Research Institute
Publications - 8
Citations - 136
Jelagat Cheruiyot is an academic researcher from Kenya Medical Research Institute. The author has contributed to research in topics: Plasmodium falciparum & Malaria. The author has an hindex of 6, co-authored 8 publications receiving 113 citations. Previous affiliations of Jelagat Cheruiyot include United States Army Medical Research Unit-Kenya.
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Journal ArticleDOI
Analysis of major genome loci underlying artemisinin resistance and pfmdr1 copy number in pre- and post-ACTs in western Kenya.
Bidii S. Ngalah,Luiser A. Ingasia,Agnes C. Cheruiyot,Lorna J. Chebon,Lorna J. Chebon,Dennis W. Juma,Peninah Muiruri,Peninah Muiruri,Irene Onyango,Jack Ogony,Redemptah Yeda,Jelagat Cheruiyot,Emmanuel Mbuba,Grace Mwangoka,Angela O. Achieng,Angela O. Achieng,Zipporah Ng’ang’a,Ben Andagalu,Hoseah M. Akala,Edwin Kamau +19 more
TL;DR: Data showed SNPs on chromosome 13 and 14 had different frequency and trend in western Kenya parasites compared SEA, and suggests genetic signature of artemisinin resistance in Africa might be different from SEA.
Journal ArticleDOI
Polymorphisms in Pfmdr1, Pfcrt, and Pfnhe1 Genes Are Associated with Reduced In Vitro Activities of Quinine in Plasmodium falciparum Isolates from Western Kenya
Jelagat Cheruiyot,Luicer A. Ingasia,Angela A. Omondi,Angela A. Omondi,Dennis W. Juma,Benjamin Opot,J.M. Ndegwa,J.M. Ndegwa,Joan Mativo,Agnes C. Cheruiyot,Agnes C. Cheruiyot,Redemptah Yeda,Charles Okudo,Peninah Muiruri,Ngalah S. Bidii,Lorna J. Chebon,Paul Oyieng’ Ang’ienda,Fredrick Eyase,Jacob D. Johnson,Wallace D. Bulimo,Ben Andagalu,Hoseah M. Akala,Edwin Kamau +22 more
TL;DR: Clinical efficacy studies are now required to confirm the validity of these markers and the importance of parasite genetic background, and the mechanisms of action and resistance have not been fully elucidated.
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Trends in drug resistance codons in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in Kenyan parasites from 2008 to 2012
Dennis W. Juma,Angela A. Omondi,Luiser A. Ingasia,Benjamin Opot,Agnes C. Cheruiyot,Redemptah Yeda,Charles Okudo,Jelagat Cheruiyot,Peninnah Muiruri,Bidii S. Ngalah,Lorna J. Chebon,Fredrick Eyase,Jacob D. Johnson,Wallace D. Bulimo,Hoseah M. Akala,Ben Andagalu,Edwin Kamau +16 more
TL;DR: SP resistance is still persistently high in western Kenya, which is likely due to fixation of key mutations in the PFDhfr and Pfdhps genes as well as drug pressure from other antifolate drugs being used for the treatment of malaria and other infections.
Journal ArticleDOI
Genetic variability and population structure of Plasmodium falciparum parasite populations from different malaria ecological regions of Kenya.
TL;DR: The authors' data suggest high genetic diversity in Kenyan parasite population with the exception of parasite from Malindi where malaria has been on the decline, and the presence of significant LD suggests that there is occurrence of inbreeding in the parasite population.
Journal ArticleDOI
The Genotypic and Phenotypic Stability of Plasmodium falciparum Field Isolates in Continuous In Vitro Culture.
Redemptah Yeda,Luicer A. Ingasia,Agnes C. Cheruiyot,Charles Okudo,Lorna J. Chebon,Lorna J. Chebon,Jelagat Cheruiyot,Hoseah M. Akala,Edwin Kamau +8 more
TL;DR: Genotypic and phenotypic profiles for the three parasite-lines fluctuated from one generation to the next with no specific pattern or periodicity, which indicates parasite genetic information obtained even in short cultures is likely to be different from the natural infection parasites.