B
Benjamin Opot
Researcher at Kenya Medical Research Institute
Publications - 31
Citations - 187
Benjamin Opot is an academic researcher from Kenya Medical Research Institute. The author has contributed to research in topics: Malaria & Plasmodium falciparum. The author has an hindex of 6, co-authored 22 publications receiving 126 citations. Previous affiliations of Benjamin Opot include United States Army Medical Research Unit-Kenya & United States Department of the Army.
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Journal ArticleDOI
Temporal trends in prevalence of Plasmodium falciparum molecular markers selected for by artemether–lumefantrine treatment in pre-ACT and post-ACT parasites in western Kenya
Angela O. Achieng,Peninah Muiruri,Luicer A. Ingasia,Benjamin Opot,Dennis W. Juma,Redemptah Yeda,Bidii S. Ngalah,Bernhards Ogutu,Ben Andagalu,Hoseah M. Akala,Edwin Kamau +10 more
TL;DR: There is a significant change in parasite genotype, with key molecular determinants of AL selection almost reaching saturation, and there is need to closely monitor parasite genotypic, phenotypic and clinical dynamics in response to continued use of AL in western Kenya.
Journal ArticleDOI
Polymorphisms in Pfmdr1, Pfcrt, and Pfnhe1 Genes Are Associated with Reduced In Vitro Activities of Quinine in Plasmodium falciparum Isolates from Western Kenya
Jelagat Cheruiyot,Luicer A. Ingasia,Angela A. Omondi,Angela A. Omondi,Dennis W. Juma,Benjamin Opot,J.M. Ndegwa,J.M. Ndegwa,Joan Mativo,Agnes C. Cheruiyot,Agnes C. Cheruiyot,Redemptah Yeda,Charles Okudo,Peninah Muiruri,Ngalah S. Bidii,Lorna J. Chebon,Paul Oyieng’ Ang’ienda,Fredrick Eyase,Jacob D. Johnson,Wallace D. Bulimo,Ben Andagalu,Hoseah M. Akala,Edwin Kamau +22 more
TL;DR: Clinical efficacy studies are now required to confirm the validity of these markers and the importance of parasite genetic background, and the mechanisms of action and resistance have not been fully elucidated.
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Plasmodium interspecies interactions during a period of increasing prevalence of Plasmodium ovale in symptomatic individuals seeking treatment: an observational study
Hoseah M. Akala,Oliver J Watson,Kenneth K Mitei,Dennis W. Juma,Robert Verity,Luicer Anne Olubayo Ingasia,Benjamin Opot,Raphael Okoth,Gladys C. Chemwor,Jackline A. Juma,Edwin W. Mwakio,Nicholas F Brazeau,Agnes C. Cheruiyot,Redemptah Yeda,Maureen N. Maraka,Charles O. Okello,David P. Kateete,Jim Ray Managbanag,Ben Andagalu,Bernhards Ogutu,Edwin Kamau,Edwin Kamau,Edwin Kamau +22 more
TL;DR: The results show a prevalence of non-falciparum species infections of 27·5% among symptomatic individuals presenting at care facilities, which is higher than expected from previous cross-sectional surveys and could threaten the malaria control efforts in Kenya and pose increased risk of malaria to travellers.
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Trends in drug resistance codons in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in Kenyan parasites from 2008 to 2012
Dennis W. Juma,Angela A. Omondi,Luiser A. Ingasia,Benjamin Opot,Agnes C. Cheruiyot,Redemptah Yeda,Charles Okudo,Jelagat Cheruiyot,Peninnah Muiruri,Bidii S. Ngalah,Lorna J. Chebon,Fredrick Eyase,Jacob D. Johnson,Wallace D. Bulimo,Hoseah M. Akala,Ben Andagalu,Edwin Kamau +16 more
TL;DR: SP resistance is still persistently high in western Kenya, which is likely due to fixation of key mutations in the PFDhfr and Pfdhps genes as well as drug pressure from other antifolate drugs being used for the treatment of malaria and other infections.
Journal ArticleDOI
Whole genome characterization of human influenza A(H1N1)pdm09 viruses isolated from Kenya during the 2009 pandemic.
George Gachara,Samuel Symekher,Michael F. Otieno,Japheth Magana,Benjamin Opot,Wallace D. Bulimo +5 more
TL;DR: It is shown that two clades of influenza A(H1N1)pdm09 virus were introduced into Kenya from the UK and the pandemic was sustained as a result of importations.