B
Bidii S. Ngalah
Researcher at Jomo Kenyatta University of Agriculture and Technology
Publications - 6
Citations - 101
Bidii S. Ngalah is an academic researcher from Jomo Kenyatta University of Agriculture and Technology. The author has contributed to research in topics: Single-nucleotide polymorphism & Artemisinin. The author has an hindex of 5, co-authored 5 publications receiving 80 citations. Previous affiliations of Bidii S. Ngalah include Kenya Medical Research Institute & United States Army Medical Research Unit-Kenya.
Papers
More filters
Journal ArticleDOI
Temporal trends in prevalence of Plasmodium falciparum molecular markers selected for by artemether–lumefantrine treatment in pre-ACT and post-ACT parasites in western Kenya
Angela O. Achieng,Peninah Muiruri,Luicer A. Ingasia,Benjamin Opot,Dennis W. Juma,Redemptah Yeda,Bidii S. Ngalah,Bernhards Ogutu,Ben Andagalu,Hoseah M. Akala,Edwin Kamau +10 more
TL;DR: There is a significant change in parasite genotype, with key molecular determinants of AL selection almost reaching saturation, and there is need to closely monitor parasite genotypic, phenotypic and clinical dynamics in response to continued use of AL in western Kenya.
Journal ArticleDOI
Analysis of major genome loci underlying artemisinin resistance and pfmdr1 copy number in pre- and post-ACTs in western Kenya.
Bidii S. Ngalah,Luiser A. Ingasia,Agnes C. Cheruiyot,Lorna J. Chebon,Lorna J. Chebon,Dennis W. Juma,Peninah Muiruri,Peninah Muiruri,Irene Onyango,Jack Ogony,Redemptah Yeda,Jelagat Cheruiyot,Emmanuel Mbuba,Grace Mwangoka,Angela O. Achieng,Angela O. Achieng,Zipporah Ng’ang’a,Ben Andagalu,Hoseah M. Akala,Edwin Kamau +19 more
TL;DR: Data showed SNPs on chromosome 13 and 14 had different frequency and trend in western Kenya parasites compared SEA, and suggests genetic signature of artemisinin resistance in Africa might be different from SEA.
Journal ArticleDOI
Trends in drug resistance codons in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in Kenyan parasites from 2008 to 2012
Dennis W. Juma,Angela A. Omondi,Luiser A. Ingasia,Benjamin Opot,Agnes C. Cheruiyot,Redemptah Yeda,Charles Okudo,Jelagat Cheruiyot,Peninnah Muiruri,Bidii S. Ngalah,Lorna J. Chebon,Fredrick Eyase,Jacob D. Johnson,Wallace D. Bulimo,Hoseah M. Akala,Ben Andagalu,Edwin Kamau +16 more
TL;DR: SP resistance is still persistently high in western Kenya, which is likely due to fixation of key mutations in the PFDhfr and Pfdhps genes as well as drug pressure from other antifolate drugs being used for the treatment of malaria and other infections.
Journal ArticleDOI
Selective sweeps and genetic lineages of Plasmodium falciparum multi-drug resistance ( pfmdr1 ) gene in Kenya
Peninah Muiruri,Peninah Muiruri,Denis W. Juma,Luicer A. Ingasia,Lorna J. Chebon,Benjamin Opot,Bidii S. Ngalah,Jelagat Cheruiyot,Ben Andagalu,Hoseah M. Akala,Venny C. S. Nyambati,Joseph K. Ng’ang’a,Edwin Kamau,Edwin Kamau +13 more
TL;DR: Evidence of selective sweep and genetic lineages in pfmdr1 genotypes associated with the use of artemether–lumefantrine, as the first-line treatment in Kenya are investigated to show effective malaria control policies should be based on the region and not at a country wide level.
Journal ArticleDOI
Genetically Determined Response to Artemisinin Treatment in Western Kenyan Plasmodium falciparum Parasites
Lorna J. Chebon,Lorna J. Chebon,Bidii S. Ngalah,Bidii S. Ngalah,Luicer A. Ingasia,Dennis W. Juma,Peninah Muiruri,Peninah Muiruri,Jelagat Cheruiyot,Benjamin Opot,Emmanuel Mbuba,Mabel Imbuga,Hoseah M. Akala,Wallace D. Bulimo,Ben Andagalu,Edwin Kamau +15 more
TL;DR: Whether genetics provides a basis for discovering molecular markers in response to artemisinin drug treatment in P. falciparum in Kenya is attempted to elucidate and SNPs revealed might have some causal association with parasite clearance rates are revealed.