Angela Taddei

TL;DR: The results show that both H3-K9 acetylation and methylation can occur on independent sets of H3 molecules in pericentric heterochromatin, and identify an RNA- and histone modification–dependent structure that brings methylated H1 protein–binding tails together in a specific configuration required for the accumulation of HP1 proteins in these domains.

TL;DR: It is reported that transcriptional activation of a subtelomeric gene, HXK1 (hexokinase isoenzyme 1), by growth on a non-glucose carbon source led to its relocalization to nuclear pores, and that nuclear position has an active role in determining optimal gene expression levels.

TL;DR: It is shown that pericentric heterochromatin in mammalian cells is specifically responsive to prolonged treatment with deacetylase inhibitors, and this data point to a crucial role of histone underacetylation within perICentric heterchromatin regions for their association with HP1 proteins, their nuclear compartmentalization and their contribution to centromere function.

TL;DR: The first unambiguous identification of protein interactions that are both necessary and sufficient to localize chromatin to the nuclear envelope is provided, and it is demonstrated that Ku‐ and Esc1‐dependent pathways mediate natural telomere anchoring in vivo.

TL;DR: This review examines functional implications of the long-range organization of the genome in interphase nuclei, general concepts of interphase nuclear order, the role of the nuclear envelope and lamins, and the importance of spatial organization for DNA replication and heritable gene expression.