Christèle Maison

TL;DR: The results show that both H3-K9 acetylation and methylation can occur on independent sets of H3 molecules in pericentric heterochromatin, and identify an RNA- and histone modification–dependent structure that brings methylated H1 protein–binding tails together in a specific configuration required for the accumulation of HP1 proteins in these domains.

TL;DR: It is shown that centric and pericentric repeats on the chromosomes have distinct heterochromatic characteristics in the nucleus, and spatio-temporal isolation is proposed to be important for centromeric cohesion and dissociation during chromosome segregation.

TL;DR: It is shown that pericentric heterochromatin in mammalian cells is specifically responsive to prolonged treatment with deacetylase inhibitors, and this data point to a crucial role of histone underacetylation within perICentric heterchromatin regions for their association with HP1 proteins, their nuclear compartmentalization and their contribution to centromere function.

TL;DR: A link is established between the SUV39H1–H3K9me3–HP1α pathway and the stability of TH2 cells, and they identify potential targets for therapeutic intervention in TH2-cell-mediated inflammatory diseases.

TL;DR: The presence of long nuclear noncoding transcripts corresponding to major satellite repeats at the periphery of pericentric heterochromatin is revealed and it is found that major transcripts in the forward orientation specifically associate with SUMO-modified HP1 proteins.