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Angèle T. Parent
Researcher at University of Chicago
Publications - 37
Citations - 2763
Angèle T. Parent is an academic researcher from University of Chicago. The author has contributed to research in topics: Amyloid precursor protein & Presenilin. The author has an hindex of 23, co-authored 37 publications receiving 2589 citations. Previous affiliations of Angèle T. Parent include Johns Hopkins University School of Medicine & National Institutes of Health.
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Journal ArticleDOI
d-Serine is an endogenous ligand for the glycine site of the N-methyl-d-aspartate receptor
Jean-Pierre Mothet,Angèle T. Parent,Angèle T. Parent,Herman Wolosker,Roscoe O. Brady,David J. Linden,Christopher D. Ferris,Michael A. Rogawski,Solomon H. Snyder +8 more
TL;DR: D-serine is an endogenous modulator of the glycine site of NMDA receptors and fully occupies this site at some functional synapses and greatly attenuates NMDA receptor-mediated neurotransmission as assessed by using whole-cell patch-clamp recordings or indirectly by using biochemical assays of the sequelae of NMda receptor- mediated calcium flux.
Journal ArticleDOI
Facilitation of acetylcholine release and cognitive performance by an M(2)-muscarinic receptor antagonist in aged memory-impaired
Rémi Quirion,A. Wilson,W Rowe,Isabelle Aubert,John Lalith Charles Richard,H Doods,Angèle T. Parent,N White,Michael J. Meaney +8 more
TL;DR: Interestingly, the muscarinic M2 antagonist BIBN-99 reversed, in a dose-dependent manner, the impaired ACh release as well as the cognitive deficits observed in the AI group, which may have implications for the treatment of degenerative disorders associated with impaired cholinergic functions, such as Alzheimer's disease.
Journal ArticleDOI
Impaired cerebellar long-term potentiation in type I adenylyl cyclase mutant mice.
TL;DR: This work has used mutant mice in which the major Ca-sensitive adenylyl cyclase isoform of cerebellar cortex (type I) is deleted to show that this results in an approximately 65% reduction in Cerebellar Ca- sensitive cyclase activity and a nearly complete blockade of cerebelar LTP.
Journal ArticleDOI
Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1.
TL;DR: Data suggest that the FAD-linked A246E variant of PS1 leads to higher degree of LTP induction in mice, and the function relating fiber volley amplitude to fEPSP slope is an index of basal synaptic strength.
Journal ArticleDOI
Mechanisms of Disease: new therapeutic strategies for Alzheimer's disease—targeting APP processing in lipid rafts
Haipeng Cheng,Kulandaivelu S. Vetrivel,Ping Gong,Xavier Meckler,Angèle T. Parent,Gopal Thinakaran +5 more
TL;DR: Recent findings regarding the association of BACE1, γ-secretase and APP in lipid rafts are reviewed, and potential therapeutic strategies for AD are discussed based on knowledge gleaned from the membrane environment that fosters APP processing.