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Anh Tuan Nguyen
Researcher at National University of Singapore
Publications - 11
Citations - 618
Anh Tuan Nguyen is an academic researcher from National University of Singapore. The author has contributed to research in topics: Zebrafish & Transgene. The author has an hindex of 9, co-authored 11 publications receiving 525 citations. Previous affiliations of Anh Tuan Nguyen include Oregon State University & Agency for Science, Technology and Research.
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Journal ArticleDOI
An inducible krasV12 transgenic zebrafish model for liver tumorigenesis and chemical drug screening
Anh Tuan Nguyen,Alexander Emelyanov,Chor Hui Vivien Koh,Jan M. Spitsbergen,Serguei Parinov,Zhiyuan Gong +5 more
TL;DR: This mifepristone-inducible and reversible krasV12 transgenic system offers a novel model for understanding hepatocarcinogenesis and a high-throughput screening platform for anti-cancer drugs.
Journal ArticleDOI
Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model
Emilie A. Bard-Chapeau,Anh Tuan Nguyen,Alistair G. Rust,Ahmed Sayadi,Philip Lee,Belinda Q. Chua,Lee Sun New,Johann de Jong,Jerrold M. Ward,Christopher K Y Chin,Valerie Chew,Han Chong Toh,Jean Pierre Abastado,Touati Benoukraf,Richie Soong,Frederic Bard,Adam J. Dupuy,Randy L. Johnson,George K. Radda,Eric Chun Yong Chan,Lodewyk F. A. Wessels,David J. Adams,Nancy A. Jenkins,Neal G. Copeland +23 more
TL;DR: This study provides a comprehensive overview of the genetic landscape of HCC, with a striking 1,199 genes being linked to cellular metabolic processes and a very large number of candidate later stage drivers enriched for genes that are mutated, deregulated or functioning in signaling pathways important for human HCC.
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Organelle Specific O-Glycosylation Drives MMP14 Activation, Tumor Growth, and Metastasis.
Anh Tuan Nguyen,Joanne Chia,Manon Ros,Kam M. Hui,Frédéric Saltel,Frédéric Saltel,Frederic Bard,Frederic Bard +7 more
TL;DR: It is shown that GALNTs strongly promote liver tumor growth after relocating to the ER, and unlike its Golgi-localized counterpart, ER-G1 glycosylates the matrix metalloproteinase MMP14, a process required for tumor expansion.
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A high level of liver-specific expression of oncogenic KrasV12 drives robust liver tumorigenesis in transgenic zebrafish
Anh Tuan Nguyen,Alexander Emelyanov,Chor Hui Vivien Koh,Jan M. Spitsbergen,Siew Hong Lam,Sinnakaruppan Mathavan,Serguei Parinov,Zhiyuan Gong +7 more
TL;DR: A comprehensive portrait of molecular mechanisms during progressive Ras-induced HCC is presented, which indicates the validity of the transgenic zebrafish to model human liver cancer, and this model might act as a useful platform for drug screening and identifying new therapeutic targets.
Journal ArticleDOI
Xmrk, kras and myc transgenic zebrafish liver cancer models share molecular signatures with subsets of human hepatocellular carcinoma.
TL;DR: These transgenic zebrafish models with well-defined oncogene-induced tumors are valuable tools for molecular classification of human HCCs and for understanding of molecular drivers in hepatocarcinogenesis in each human H CC subgroup.