J
Jose Oberholzer
Researcher at University of Virginia
Publications - 355
Citations - 16221
Jose Oberholzer is an academic researcher from University of Virginia. The author has contributed to research in topics: Transplantation & Islet. The author has an hindex of 60, co-authored 326 publications receiving 14071 citations. Previous affiliations of Jose Oberholzer include University of Virginia Health System & University of Alberta.
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Journal ArticleDOI
Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets
Kathrin Maedler,Pavel Sergeev,Frédéric Ris,Jose Oberholzer,Helen I. Joller-Jemelka,Giatgen A. Spinas,Nurit Kaiser,Philippe A. Halban,Marc Y. Donath +8 more
TL;DR: In vitro exposure of islets from nondiabetic organ donors to high glucose levels resulted in increased production and release of IL-1beta, followed by NF-kappaB activation, Fas upregulation, DNA fragmentation, and impaired beta cell function, which implicate an inflammatory process in the pathogenesis of glucotoxicity in type 2 diabetes.
Journal ArticleDOI
Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates
Omid Veiseh,Joshua C. Doloff,Minglin Ma,Arturo J. Vegas,Hok Hei Tam,Andrew Bader,Jie Li,Erin Langan,Jeffrey Wyckoff,Whitney S. Loo,Siddharth Jhunjhunwala,Alan Chiu,Sean M. Siebert,Katherine Tang,Jennifer Hollister-Lock,Stephanie Aresta-Dasilva,Matthew A. Bochenek,Joshua E. Mendoza-Elias,Yong Wang,Merigeng Qi,Danya M. Lavin,Michael Chen,Nimit Dholakia,Raj Thakrar,Igor Lacík,Gordon C. Weir,Jose Oberholzer,Dale L. Greiner,Robert Langer,Daniel G. Anderson +29 more
TL;DR: In this paper, a broad variety of material classes significantly abrogate foreign body reactions and fibrosis in rodent and non-human primates when the spheres are larger than 1.5 mm in diameter.
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Improvement in outcomes of clinical islet transplantation: 1999-2010.
Franca B. Barton,Michael R. Rickels,Rodolfo Alejandro,Bernhard J. Hering,Stephen Wease,Bashoo Naziruddin,Jose Oberholzer,Jon S. Odorico,Marc R. Garfinkel,Marlon F. Levy,François Pattou,Thierry Berney,Antonio Secchi,Shari Messinger,Peter A. Senior,Paola Maffi,Andrew M. Posselt,Peter G. Stock,Dixon B. Kaufman,Xunrong Luo,Fouad Kandeel,Enrico Cagliero,Nicole A. Turgeon,Piotr Witkowski,Ali Naji,Philip J. O'Connell,Carla J. Greenbaum,Yogish C. Kudva,Kenneth L. Brayman,Meredith J. Aull,Christian P. Larsen,Thomas W.H. Kay,Luis A. Fernandez,Marie-Christine Vantyghem,Melena D. Bellin,A. M. James Shapiro +35 more
TL;DR: The CITR shows improvement in primary efficacy and safety outcomes of islet transplantation in recipients who received transplants in 2007–2010 compared with those in 1999–2006, with fewer islet infusions and adverse events per recipient.
Journal ArticleDOI
Monounsaturated Fatty Acids Prevent the Deleterious Effects of Palmitate and High Glucose on Human Pancreatic β-Cell Turnover and Function
TL;DR: In human islets, the saturated palmitic acid and elevated glucose concentration induce beta-cell apoptosis, decreasebeta-cell proliferation, and impair beta- cell function, which can be prevented by monounsaturated fatty acids.
Journal ArticleDOI
Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice
Arturo J. Vegas,Arturo J. Vegas,Arturo J. Vegas,Omid Veiseh,Omid Veiseh,Mads Gürtler,Jeffrey R. Millman,Felicia W. Pagliuca,Andrew Bader,Andrew Bader,Andrew Bader,Joshua C. Doloff,Joshua C. Doloff,Jie Li,Jie Li,Michael Chen,Michael Chen,Karsten Olejnik,Karsten Olejnik,Hok Hei Tam,Hok Hei Tam,Siddharth Jhunjhunwala,Siddharth Jhunjhunwala,Erin Langan,Erin Langan,Stephanie Aresta-Dasilva,Stephanie Aresta-Dasilva,Srujan Gandham,Srujan Gandham,James J. McGarrigle,Matthew A. Bochenek,Jennifer Hollister-Lock,Jose Oberholzer,Dale L. Greiner,Gordon C. Weir,Douglas A. Melton,Douglas A. Melton,Robert Langer,Daniel G. Anderson +38 more
TL;DR: The first long-term glycemic correction of a diabetic, immunocompetent animal model using human SC-β cells is reported, which induced glycemic Correction without any immunosuppression until their removal at 174 d after implantation.