Jennifer S. Liu

TL;DR: PLX4720, a 7-azaindole derivative that inhibits B-RafV600E with an IC50 of 13 nM, defines a class of kinase inhibitor with marked selectivity in both biochemical and cellular assays and represents the entire discovery process from initial identification through structural and biological studies in animal models to a promising therapeutic for testing in cancer patients bearing B- RafV 600E-driven tumors.

TL;DR: Replicating aspects of endocrine cell clustering permits the generation of stem-cell-derived β cells that resemble their endogenous counterparts, including robust dynamic insulin secretion and mitochondrial oxidative respiration.

TL;DR: This is the first study to report a significant association of a polymorphism in ERCC1 with the risk of brain tumors, which results in an amino acid substitution of lysine to glutamine in a recently described nucleolar protein (ASE-1) and T-cell receptor complex subunit CD3epsilon-associated signal transducer (CAST).

TL;DR: The utility of this strategy for chemically controlling cell adhesion using membrane-anchored single-stranded DNA oligonucleotides is demonstrated by imaging drug-induced changes in the membrane dynamics of non-adherent human cells that are chemically immobilized on a passivated glass surface.

TL;DR: Methods for the bottom-up and directed assembly of modular, multicellular, and tissue-like constructs in vitro will help refine the understanding of the relationship between form and function in the human body, provide new models for the breakdown in tissue architecture that accompanies disease, and serve as building blocks for the field of regenerative medicine.