Y
Yong Wang
Researcher at University of Virginia
Publications - 74
Citations - 3578
Yong Wang is an academic researcher from University of Virginia. The author has contributed to research in topics: Transplantation & Islet. The author has an hindex of 28, co-authored 74 publications receiving 2811 citations. Previous affiliations of Yong Wang include University of Illinois at Chicago.
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Journal ArticleDOI
Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates
Omid Veiseh,Joshua C. Doloff,Minglin Ma,Arturo J. Vegas,Hok Hei Tam,Andrew Bader,Jie Li,Erin Langan,Jeffrey Wyckoff,Whitney S. Loo,Siddharth Jhunjhunwala,Alan Chiu,Sean M. Siebert,Katherine Tang,Jennifer Hollister-Lock,Stephanie Aresta-Dasilva,Matthew A. Bochenek,Joshua E. Mendoza-Elias,Yong Wang,Merigeng Qi,Danya M. Lavin,Michael Chen,Nimit Dholakia,Raj Thakrar,Igor Lacík,Gordon C. Weir,Jose Oberholzer,Dale L. Greiner,Robert Langer,Daniel G. Anderson +29 more
TL;DR: In this paper, a broad variety of material classes significantly abrogate foreign body reactions and fibrosis in rodent and non-human primates when the spheres are larger than 1.5 mm in diameter.
Journal ArticleDOI
Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells.
Gopika G. Nair,Jennifer S. Liu,Holger A. Russ,Holger A. Russ,Stella Tran,Stella Tran,Michael S Saxton,Richard Chen,Charity Juang,Mei-Lan Li,Vinh Son Nguyen,Simone Giacometti,Sapna Puri,Yuan Xing,Yong Wang,Gregory L. Szot,Jose Oberholzer,Anil Bhushan,Matthias Hebrok +18 more
TL;DR: Replicating aspects of endocrine cell clustering permits the generation of stem-cell-derived β cells that resemble their endogenous counterparts, including robust dynamic insulin secretion and mitochondrial oxidative respiration.
Journal ArticleDOI
Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques.
Matthew A. Bochenek,Omid Veiseh,Arturo J. Vegas,James J. McGarrigle,Meirigeng Qi,Enza Marchese,Mustafa Omami,Joshua C. Doloff,Joshua C. Doloff,Joshua E. Mendoza-Elias,Mohammad Nourmohammadzadeh,Mohammad Nourmohammadzadeh,Arshad Khan,Chun Chieh Yeh,Yuan Xing,Yuan Xing,Douglas Isa,Sofia Ghani,Jie Li,Casey E. Landry,Casey E. Landry,Andrew Bader,Andrew Bader,Karsten Olejnik,Michael Chen,Michael Chen,Jennifer Hollister-Lock,Yong Wang,Yong Wang,Dale L. Greiner,Gordon C. Weir,Berit L. Strand,Anne Mari Rokstad,Igor Lacík,Robert Langer,Daniel G. Anderson,Jose Oberholzer,Jose Oberholzer +37 more
TL;DR: Transplantation of pancreatic islet cells encapsulated in alginate microspheres into the omental bursa of the peritoneal cavity of NHPs significantly reduces FBRs and extends the longevity of the cells.
Journal ArticleDOI
Islet Transplantation for Brittle Type 1 Diabetes: The UIC Protocol
Antonio Gangemi,Payam Salehi,Betul Hatipoglu,Joan Martellotto,Barbara Barbaro,Joseph Kuechle,Meirigeng Qi,Yong Wang,P. Pallan,Charles A. Owens,James T. Bui,Derek L. West,Bruce Kaplan,Enrico Benedetti,Jose Oberholzer +14 more
TL;DR: Combined treatment of etanercept and exenatide improves islet graft function and facilitates achievement of insulin‐independence with less islets in type I diabetic patients.
Journal ArticleDOI
Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx
Harini Chakravarthy,Xueying Gu,Martin Enge,Xiao-Qing Dai,Yong Wang,Nicolas Damond,Carolina Downie,K. Liu,Jing Wang,Yuan Xing,Simona Chera,Fabrizio Thorel,Stephen R. Quake,Jose Oberholzer,Patrick E. MacDonald,Pedro Luis Herrera,Seung K. Kim +16 more
TL;DR: This work reveals pathways regulated by Arx and Dnmt1 that are sufficient for achieving targeted generation of β cells from adult pancreatic α cells.