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Anjli Kukreja
Researcher at Rockefeller University
Publications - 8
Citations - 1185
Anjli Kukreja is an academic researcher from Rockefeller University. The author has contributed to research in topics: Dendritic cell & Antigen. The author has an hindex of 8, co-authored 8 publications receiving 1114 citations.
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Journal ArticleDOI
Sustained expansion of NKT cells and antigen-specific T cells after injection of α-galactosyl-ceramide loaded mature dendritic cells in cancer patients
David H. Chang,Keren Osman,John Connolly,Anjli Kukreja,Joseph Krasovsky,Maggi Pack,Aisha Hutchinson,Matthew D. Geller,Nancy Liu,Rebecca Annable,Jennifer Shay,Kelly Kirchhoff,Nobusuke Nishi,Yoshitaka Ando,Kunihiko Hayashi,Hani Hassoun,Ralph M. Steinman,Madhav V. Dhodapkar,Madhav V. Dhodapkar +18 more
TL;DR: The feasibility of sustained expansion of NKT cells in vivo in humans, including patients who have advanced cancer, is demonstrated and it is suggested that NKT activation might help to boost adaptive T cell immunity in vivo.
Journal ArticleDOI
Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma
Kavita M. Dhodapkar,Scott Barbuto,Phillip Matthews,Anjli Kukreja,Amitabha Mazumder,David H. Vesole,Sundar Jagannath,Madhav V. Dhodapkar,Madhav V. Dhodapkar,Madhav V. Dhodapkar +9 more
TL;DR: The capacity of DCs to induce expansion of polyfunctional IL17-producing T cells in humans is demonstrated, and a role for DCs is suggested in the enrichment of Th17-1 cells in the tumor bed.
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Frequent and specific immunity to the embryonal stem cell–associated antigen SOX2 in patients with monoclonal gammopathy
Radek Spisek,Anjli Kukreja,Lin-Chi Chen M.D.,Phillip Matthews,Amitabha Mazumder,David H. Vesole,Sundar Jagannath,Henry Zebroski,Andrew J. G. Simpson,Gerd Ritter,Brian G.M. Durie,John Crowley,John D. Shaughnessy,Matthew J. Scanlan,Ali O. Gure,Ali O. Gure,Bart Barlogie,Madhav V. Dhodapkar +17 more
TL;DR: It is shown that antigenic targets of spontaneous immunity in MGUS differ from MM, and detection of anti-SOX2 T cells predicts favorable clinical outcome in patients with asymptomatic plasmaproliferative disorders.
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Enhancement of clonogenicity of human multiple myeloma by dendritic cells
Anjli Kukreja,Aisha Hutchinson,Kavita M. Dhodapkar,Amitabha Mazumder,David H. Vesole,Revathi Angitapalli,Sundar Jagannath,Madhav V. Dhodapkar +7 more
TL;DR: It is shown that the clonogenicity of several human tumor cell lines and primary tumor cells from myeloma patients is enhanced by their interactions with dendritic cells, suggesting that tumor–DC interactions may directly impact the biology of human tumors, particularly multipleMyeloma, and may be a target for therapeutic intervention.
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Selective blockade of the inhibitory Fcγ receptor (FcγRIIB) in human dendritic cells and monocytes induces a type I interferon response program
Kavita M. Dhodapkar,Devi Banerjee,John E. Connolly,Anjli Kukreja,Elyana Matayeva,Maria Concetta Veri,Jeffrey V. Ravetch,Ralph M. Steinman,Madhav V. Dhodapkar +8 more
TL;DR: It is shown that Fcγ receptor (FcγR)–mediated activation of human monocytes and monocyte-derived DCs is associated with a distinct gene expression pattern, including several inflammation-associated chemokines, as well as type 1 interferon (IFN) response genes, including the activation of signal transducer and activation of transcription 1 (STAT1).