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David H. Chang
Researcher at Rockefeller University
Publications - 7
Citations - 1289
David H. Chang is an academic researcher from Rockefeller University. The author has contributed to research in topics: Natural killer T cell & Antigen. The author has an hindex of 6, co-authored 6 publications receiving 1221 citations.
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Journal ArticleDOI
Sustained expansion of NKT cells and antigen-specific T cells after injection of α-galactosyl-ceramide loaded mature dendritic cells in cancer patients
David H. Chang,Keren Osman,John Connolly,Anjli Kukreja,Joseph Krasovsky,Maggi Pack,Aisha Hutchinson,Matthew D. Geller,Nancy Liu,Rebecca Annable,Jennifer Shay,Kelly Kirchhoff,Nobusuke Nishi,Yoshitaka Ando,Kunihiko Hayashi,Hani Hassoun,Ralph M. Steinman,Madhav V. Dhodapkar,Madhav V. Dhodapkar +18 more
TL;DR: The feasibility of sustained expansion of NKT cells in vivo in humans, including patients who have advanced cancer, is demonstrated and it is suggested that NKT activation might help to boost adaptive T cell immunity in vivo.
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A reversible defect in natural killer T cell function characterizes the progression of premalignant to malignant multiple myeloma.
Madhav V. Dhodapkar,Madhav V. Dhodapkar,Matthew D. Geller,David H. Chang,Kanako Shimizu,Shin-ichiro Fujii,Kavita M. Dhodapkar,Joseph Krasovsky +7 more
TL;DR: Clinical progression in patients with monoclonal gammopathies is associated with an acquired but potentially reversible defect in NKT cell function and support the possibility that these innate lymphocytes play a role in controlling the malignant growth of this incurable B cell tumor in patients.
Journal ArticleDOI
Enhancement of ligand-dependent activation of human natural killer T cells by lenalidomide: therapeutic implications
David H. Chang,Nancy Liu,Nancy Liu,Virginia M. Klimek,Virginia M. Klimek,Hani Hassoun,Hani Hassoun,Amitabha Mazumder,Amitabha Mazumder,Stephen D. Nimer,Stephen D. Nimer,Sundar Jagannath,Sundar Jagannath,Madhav V. Dhodapkar,Madhav V. Dhodapkar +14 more
TL;DR: It is demonstrated that LEN and its analogues enhance CD1d-mediated presentation of glycolipid antigens and support combining these agents with NKT targeted approaches for protection against tumors.
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Inflammation-associated lysophospholipids as ligands for CD1d-restricted T cells in human cancer.
David H. Chang,Haiteng Deng,Phillip Matthews,Joseph Krasovsky,Govind Ragupathi,Radek Spisek,Amitabha Mazumder,David H. Vesole,Sundar Jagannath,Madhav V. Dhodapkar +9 more
TL;DR: A biochemical approach is taken to directly isolate and characterize the nature of CD1d-binding ligands from the plasma of myeloma patients to suggest a novel mechanism for inflammation mediated immune regulation in human cancer.
Journal ArticleDOI
Dendritic cells and immunotherapy for cancer.
TL;DR: Early studies of adoptive transfer of tumor antigen-loaded DCs have shown promise, however, DC vaccination is at an early stage, and several parameters still need to be established.