K
Kunihiko Hayashi
Publications - 4
Citations - 570
Kunihiko Hayashi is an academic researcher. The author has contributed to research in topics: Natural killer T cell & Immunotherapy. The author has an hindex of 3, co-authored 4 publications receiving 540 citations.
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Journal ArticleDOI
Sustained expansion of NKT cells and antigen-specific T cells after injection of α-galactosyl-ceramide loaded mature dendritic cells in cancer patients
David H. Chang,Keren Osman,John Connolly,Anjli Kukreja,Joseph Krasovsky,Maggi Pack,Aisha Hutchinson,Matthew D. Geller,Nancy Liu,Rebecca Annable,Jennifer Shay,Kelly Kirchhoff,Nobusuke Nishi,Yoshitaka Ando,Kunihiko Hayashi,Hani Hassoun,Ralph M. Steinman,Madhav V. Dhodapkar,Madhav V. Dhodapkar +18 more
TL;DR: The feasibility of sustained expansion of NKT cells in vivo in humans, including patients who have advanced cancer, is demonstrated and it is suggested that NKT activation might help to boost adaptive T cell immunity in vivo.
Journal ArticleDOI
Alpha-galactosylceramide in chronic hepatitis B infection: results from a randomized placebo-controlled Phase I/II trial.
Andrea M. Woltman,Martijn J. ter Borg,Rekha S. Binda,Dave Sprengers,B. Mary E. von Blomberg,Rik J. Scheper,Kunihiko Hayashi,Nobusuke Nishi,Andre Boonstra,Renate G. van der Molen,Harry L.A. Janssen +10 more
TL;DR: A randomized placebo-controlled Phase I/II trial aimed to investigate antiviral activity and safety of alpha-GalCer as a novel class of treatment for chronic hepatitis B patients.
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Randomized placebo controlled phase I/II trial of α-galactosylceramide for the treatment of chronic hepatitis C
Bart J. Veldt,Hans van Vliet,B. Mary E. von Blomberg,Hans Van Vlierberghe,Guido Gerken,Nobusuke Nishi,Kunihiko Hayashi,Rik J. Scheper,Robert J. de Knegt,Alfons J.M. van den Eertwegh,Harry L.A. Janssen,Carin M.J. van Nieuwkerk +11 more
TL;DR: In this article, the safety and antiviral activity of α-galactosylceramide as a novel class of treatment for chronic hepatitis C patients were investigated and no patients were withdrawn due to side effects.
Journal ArticleDOI
Molecular cloning of a novel receptor-type protein tyrosine phosphatase from murine fetal liver
Takashi Yoneya,Yoko Yamada,Minoru Kakeda,Masatake Osawa,Eiko Arai,Kunihiko Hayashi,Nobusuke Nishi,Hideo Inoue,Mitsuo Nishikawa +8 more
TL;DR: A cDNA fragment encoding a novel tyrosine phosphatase (PTPase), termed ptpf, was isolated from day 11.5 mouse fetal liver using reverse transcription-polymerase chain reaction (RT-PCR) with degenerate primers and sequence analysis revealed that PTPf was homologous to PTPmu and PTPkappa, and a putative receptor-type PTPase.