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Ann Charlotte Wikström
Researcher at Karolinska Institutet
Publications - 22
Citations - 2226
Ann Charlotte Wikström is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Glucocorticoid receptor & Receptor. The author has an hindex of 15, co-authored 22 publications receiving 2203 citations. Previous affiliations of Ann Charlotte Wikström include University of California, San Francisco.
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Journal ArticleDOI
Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA
Roger L. Miesfeld,Sandro Rusconi,Paul J. Godowski,Bonnie A. Maler,Sam Okret,Ann Charlotte Wikström,Jan-Åke Gustafsson,Keith R. Yamamoto +7 more
TL;DR: The cloned receptor protein activates its corresponding enhancers, restoring to the receptor-deficient cells the full capacity for regulated enhancement.
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Characterization of a steroid hormone receptor gene and mRNA in wild-type and mutant cells
Roger L. Miesfeld,Sam Okret,Ann Charlotte Wikström,O. Wrange,Jan-Åke Gustafsson,Keith R. Yamamoto +5 more
TL;DR: Cloned complementary DNA (cDNA) for the rat liver glucocorticoid receptor is cloned and appears to be encoded by a single-copy gene which specifies a ∼6-kb transcript in rat and mouse cells; this mRNA is altered quantitatively and qualitatively in several mutant cell lines with specific defects in receptor function.
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Association of the dioxin receptor with the Mr 90,000 heat shock protein: a structural kinship with the glucocorticoid receptor.
TL;DR: It is concluded that both the dioxin and glucocorticoid receptor can form heteromeric complexes which share a common non-ligand-binding component.
Journal ArticleDOI
The specific DNA binding activity of the dioxin receptor is modulated by the 90 kd heat shock protein.
Anna Wilhelmsson,Scott Cuthill,Marc G. Denis,Ann Charlotte Wikström,Jan-Åke Gustafsson,Lorenz Poellinger +5 more
TL;DR: It is concluded that activation of the dioxin receptor is, at least, a two step process involving binding of the ligand and dissociation of hsp90 from the lig and‐binding receptor protein.
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The pregnane X receptor locus is associated with susceptibility to inflammatory bowel disease.
Megan Dring,Carol Goulding,Valerie Trimble,Denise Keegan,Anthony W. Ryan,Karen Brophy,Claire M. Smyth,P. W Napoleon Keeling,D. P. O’Donoghue,Maria O'Sullivan,Colm O'Morain,Nasir Mahmud,Ann Charlotte Wikström,Dermot Kelleher,Ross McManus +14 more
TL;DR: Results show that genetic variation in the PXR encoding gene, which has been associated with altered activity of P XR, is strongly associated with susceptibility to IBD, CD, and UC.